Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit African Swine Fever Virus Replication.

African Swine Fever African Swine Fever Virus / genetics Animals Antiviral Agents / metabolism Chlorocebus aethiops Interferons / metabolism Membrane Proteins / metabolism Swine Vero Cells Virus Replication
African swine fever virus antiviral effect interferon-inducible transmembrane protein restriction swine

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2022
Historique:
received: 02 12 2021
accepted: 04 03 2022
entrez: 11 4 2022
pubmed: 12 4 2022
medline: 13 4 2022
Statut: epublish

Résumé

African swine fever virus (ASFV) causes an acute, hemorrhagic, and highly contagious disease in domestic swine, leading to significant economic losses to the global porcine industry. Restriction factors of innate immunity play a critical in host antiviral action. However, function of swine restriction factors of innate immunity on ASFV has been seldomly investigated. In this study, we determined five homologues of swine interferon-induced transmembrane proteins (SwIFITM [named SwIFITM1a, -1b, -2, -3, and -5]), and we found that they all exhibit potent antiviral activity against ASFV. Expression profile analysis indicated that these SwIFITMs are constitutively expressed in most porcine tissues. Whether infected with ASFV or treated with swine interferon, the expression levels of SwIFITMs were induced

Identifiants

DOI: 10.3389/fimmu.2022.827709 PMID: 35401540 PMC: PMC8989734
pubmed: 35401540
doi: 10.3389/fimmu.2022.827709
pmc: PMC8989734
doi:

Substances chimiques

Antiviral Agents 0
Membrane Proteins 0
Interferons 9008-11-1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

827709

Informations de copyright

Copyright © 2022 Cai, Zheng, Cheng, Zhong, Shao, Zheng, Lai, Ou, Xu, Zhou, Lu and Zhang.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Siqi Cai (S)

Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China.
Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Maoming, China.

Zezhong Zheng (Z)

Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China.
Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China.

JiaoJiao Cheng (J)

Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China.
Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Maoming, China.

Lintao Zhong (L)

Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China.
Research Center for African Swine Fever Prevention and Control, South China Agricultural University, Guangzhou, China.

Ran Shao (R)

Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China.
Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China.

Feiyan Zheng (F)

Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China.
Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China.

Zhiying Lai (Z)

Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China.
Research Center for African Swine Fever Prevention and Control, South China Agricultural University, Guangzhou, China.

Jiajun Ou (J)

Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China.
Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China.

Liang Xu (L)

Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China.
Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China.

Pei Zhou (P)

Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China.
Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China.

Gang Lu (G)

Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China.
Research Center for African Swine Fever Prevention and Control, South China Agricultural University, Guangzhou, China.

Guihong Zhang (G)

Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China.
Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Maoming, China.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'animal › Maladies des porcs › Peste porcine africaine › Swine Interferon-Inducible Transmembrane...
questionsmedicales.fr › Virus › Virus à ADN › Asfarviridae › Virus de la peste porcine africaine › Swine Interferon-Inducible Transmembrane...
questionsmedicales.fr › Eucaryotes › Animaux › Swine Interferon-Inducible Transmembrane...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Swine Interferon-Inducible Transmembrane...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Swine Interferon-Inducible Transmembrane...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Swine Interferon-Inducible Transmembrane...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Swine Interferon-Inducible Transmembrane...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Swine Interferon-Inducible Transmembrane...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Vero › Swine Interferon-Inducible Transmembrane...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Swine Interferon-Inducible Transmembrane...