Role of Oxidative Stress in Varicocele.
DNA oxidation damage
antioxidant
infertility
oxidative stress
varicocele
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2022
2022
Historique:
received:
07
01
2022
accepted:
08
03
2022
entrez:
11
4
2022
pubmed:
12
4
2022
medline:
12
4
2022
Statut:
epublish
Résumé
According to the official statistics of the World Health Organization, at least 48 million couples and 186 million people suffer from infertility. Varicocele has been recognized as the leading cause of male infertility and can affect spermatogenesis and cause testicular and epididymal disorders through multiple diverse pathophysiological processes. Reactive oxygen species (ROS) produced by oxidative stress have been reconciled as an important pathogenic factor throughout the course of varicocele. Testis respond to heat stress, hypoxia, and inflammation at the cost of producing excessive ROS. High levels of ROS can lead to infertility not only through lipid peroxidation or DNA damage, but also by inactivating enzymes and proteins in spermatogenesis. This review studies the oxidative stress and its role in the pathophysiology and molecular biology of varicocele in the context of a decline in fertility.
Identifiants
pubmed: 35401656
doi: 10.3389/fgene.2022.850114
pii: 850114
pmc: PMC8984266
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
850114Informations de copyright
Copyright © 2022 Wang, Gao, Wang, Liang, Liao and Hu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Asian J Androl. 2016 Mar-Apr;18(2):179-81
pubmed: 26763551
J Urol. 2006 Mar;175(3 Pt 1):1045-8; discussion 1048
pubmed: 16469614
Biomed Res Int. 2015;2015:248976
pubmed: 26347229
Nat Rev Genet. 2005 Aug;6(8):633-42
pubmed: 16136654
Int J Androl. 2006 Dec;29(6):569-75
pubmed: 17121654
Fertil Steril. 2010 Jul;94(2):549-57
pubmed: 19339003
Fertil Steril. 2009 Apr;91(4 Suppl):1388-91
pubmed: 18684443
Fertil Steril. 2009 Apr;91(4 Suppl):1536-9
pubmed: 18990381
Mass Spectrom Rev. 2014 Jul-Aug;33(4):277-301
pubmed: 24930952
Hum Reprod. 1991 Jul;6(6):811-6
pubmed: 1757519
PLoS One. 2020 Apr 30;15(4):e0232357
pubmed: 32353040
J Pineal Res. 1995 Oct;19(3):111-5
pubmed: 8750343
Andrology. 2018 Sep;6(5):654-661
pubmed: 29978951
Int J Mol Sci. 2020 Apr 29;21(9):
pubmed: 32365465
J Androl. 2004 Jan-Feb;25(1):147-53
pubmed: 14662798
Andrologia. 2017 Aug;49(6):
pubmed: 27709650
Cell Mol Life Sci. 2020 Jan;77(1):93-113
pubmed: 31377843
Andrologia. 2018 Oct;50(8):e13066
pubmed: 29896906
J Urol. 1984 Jun;131(6):1208-11
pubmed: 6726930
Andrologia. 2021 Feb;53(1):e13645
pubmed: 32453911
Cell. 2010 Mar 19;140(6):821-32
pubmed: 20303873
Hum Reprod Update. 2001 Jan-Feb;7(1):78-84
pubmed: 11212079
Urology. 1996 Dec;48(6):835-50
pubmed: 8973665
Fertil Steril. 1987 Sep;48(3):510-1
pubmed: 3622800
Andrologia. 2010 Dec;42(6):389-94
pubmed: 21105890
Oncotarget. 2017 Nov 24;9(4):5105-5110
pubmed: 29435165
Int J Vitam Nutr Res. 2019 Nov;89(5-6):238-245
pubmed: 30932790
Zhonghua Nan Ke Xue. 2019 Apr;25(5):302-308
pubmed: 32216210
Bibl Anat. 1983;24:59-66
pubmed: 6847602
Andrologia. 2019 Dec;51(11):e13429
pubmed: 31613021
Andrologia. 2021 Nov;53(10):e14187
pubmed: 34309875
Asian J Androl. 2016 Mar-Apr;18(2):186-93
pubmed: 26732105
Int J Androl. 1995 Aug;18(4):169-84
pubmed: 7591190
Int J Mol Sci. 2020 Apr 30;21(9):
pubmed: 32365753
Urol Res. 2004 Jun;32(3):204-8
pubmed: 15205854
PLoS One. 2012;7(6):e38565
pubmed: 22719900
Andrologia. 2021 Mar;53(2):e13874
pubmed: 33108829
Andrologia. 2016 Apr;48(3):318-24
pubmed: 26148146
Fertil Steril. 1968 Jan-Feb;19(1):110-7
pubmed: 4952183
J Androl. 2010 May-Jun;31(3):299-305
pubmed: 20019389
Andrologia. 2007 Dec;39(6):203-15
pubmed: 18076419
Sci Rep. 2019 Mar 13;9(1):4336
pubmed: 30867501
Biol Reprod. 2021 Jun 4;104(6):1322-1336
pubmed: 33709108
Theriogenology. 2021 Mar 1;162:22-31
pubmed: 33418161
Reprod Health. 2019 Sep 2;16(1):132
pubmed: 31477152
BJU Int. 2012 Jan;109(2):259-65
pubmed: 21592296
Biol Reprod. 1985 Mar;32(2):342-51
pubmed: 3986267
J Urol. 1997 Jan;157(1):140-3
pubmed: 8976236
Biochem Biophys Res Commun. 2017 Jan 15;482(3):419-425
pubmed: 28212725
J Urol. 2004 Oct;172(4 Pt 2):1731-5; discussion 1735
pubmed: 15371801
Mol Reprod Dev. 2017 Oct;84(10):1039-1052
pubmed: 28749007
Med Chir Trans. 1846;29:259-68
pubmed: 20895849
Surgery. 2011 Feb;149(2):253-61
pubmed: 20570301
Edinb Med J. 1951-1952;59:29-34
pubmed: 24541934
Nat Rev Urol. 2012 Dec;9(12):678-90
pubmed: 23165403
Int J Mol Sci. 2021 Jan 28;22(3):
pubmed: 33525681
Free Radic Biol Med. 2021 Feb 20;164:410-416
pubmed: 33482333
Int J Urol. 2012 Jun;19(6):538-50
pubmed: 22417329
Arch Iran Med. 2010 Sep;13(5):391-4
pubmed: 20804305
Fertil Steril. 2009 May;91(5 Suppl):2247-52
pubmed: 18701100
Int Urol Nephrol. 2018 Apr;50(4):583-603
pubmed: 29542060
Mol Cell Endocrinol. 2000 Mar 30;161(1-2):67-71
pubmed: 10773394
Fertil Steril. 2014 Dec;102(6):1556-60
pubmed: 25458620
Andrologia. 2018 Oct;50(8):e13012
pubmed: 29644708
Mol Hum Reprod. 2002 Aug;8(8):719-21
pubmed: 12149402
Asian J Androl. 2016 Jan-Feb;18(1):43-53
pubmed: 25999357
Fertil Steril. 1973 Nov;24(11):854-63
pubmed: 4742006
Fertil Steril. 2013 Jan;99(1):118-124.e2
pubmed: 23040525
Int Braz J Urol. 2015 Mar-Apr;41(2):230-8
pubmed: 26005963
Andrologia. 2018 Aug;50(6):e13033
pubmed: 29740842
Asian J Androl. 2020 Sep-Oct;22(5):500-506
pubmed: 31744994
BJU Int. 2014 Apr;113(4):642-9
pubmed: 24148354
Biol Chem. 2012 Oct;393(10):1141-50
pubmed: 23091277
N Engl J Med. 1949 Jun 2;240(22):877-80
pubmed: 18144561
Annu Rev Genet. 1993;27:437-96
pubmed: 8122909
Fertil Steril. 1962 Jul-Aug;13:325-34
pubmed: 13909949
Ir J Med Sci. 2015 Jun;184(2):531-7
pubmed: 25179750
Cell Cycle. 2006 Apr;5(7):702-8
pubmed: 16582628
World J Mens Health. 2013 Apr;31(1):12-20
pubmed: 23658861
Ann Biomed Eng. 2011 Feb;39(2):664-73
pubmed: 20976556
J Assist Reprod Genet. 2014 Mar;31(3):341-54
pubmed: 24395641
Reprod Sci. 2021 Apr;28(4):1161-1174
pubmed: 33237516
Reproduction. 2014 Apr 08;147(5):693-701
pubmed: 24481955
Urology. 2015 Mar;85(3):580-8
pubmed: 25733269