The Genomic Architecture of Hidradenitis Suppurativa-A Systematic Review.
familial
gamma secretase (γ-secretase)
genetics
hidradenitis suppurativa
pathophysiology
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
01
2022
accepted:
07
03
2022
entrez:
11
4
2022
pubmed:
12
4
2022
medline:
12
4
2022
Statut:
epublish
Résumé
Hidradenitis suppurativa is a chronic, suppurative condition of the pilosebaceous unit manifesting as painful nodules, abscesses, and sinus tracts mostly in, but not limited to, intertriginous skin. Great strides have been made at elucidating the pathophysiology of hidradenitis suppurativa, which appears to be the product of hyperkeratinization and inflammation brought about by environmental factors and a genetic predisposition. The identification of familial hidradenitis suppurativa has sparked research aimed at identifying underlying pathogenic variants in patients who harbor them. The objective of this review is to provide a broad overview of the role of genetics in various aspects of hidradenitis suppurativa, specifically the pathophysiology, diagnosis, and clinical application.
Identifiants
pubmed: 35401657
doi: 10.3389/fgene.2022.861241
pii: 861241
pmc: PMC8986338
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
861241Informations de copyright
Copyright © 2022 Pace, Mintoff and Borg.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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