Anti-Fungal Drug Anidulafungin Inhibits SARS-CoV-2 Spike-Induced Syncytia Formation by Targeting ACE2-Spike Protein Interaction.

ACE2 COVID-19 MD simulations SARS-CoV-2 anidulafungin syncytia virtual screening

Journal

Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621

Informations de publication

Date de publication:
2022
Historique:
received: 31 01 2022
accepted: 01 03 2022
entrez: 11 4 2022
pubmed: 12 4 2022
medline: 12 4 2022
Statut: epublish

Résumé

Drug repositioning continues to be the most effective, practicable possibility to treat COVID-19 patients. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus enters target cells by binding to the ACE2 receptor

Identifiants

pubmed: 35401674
doi: 10.3389/fgene.2022.866474
pii: 866474
pmc: PMC8990323
doi:

Types de publication

Journal Article

Langues

eng

Pagination

866474

Informations de copyright

Copyright © 2022 Ahamad, Ali, Secco, Giacca and Gupta.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Shahzaib Ahamad (S)

Translational Bioinformatics Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.

Hashim Ali (H)

School of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London, United Kingdom.
Division of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom.

Ilaria Secco (I)

School of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London, United Kingdom.

Mauro Giacca (M)

School of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London, United Kingdom.
Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.

Dinesh Gupta (D)

Translational Bioinformatics Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.

Classifications MeSH