Case Report: Zellweger Syndrome and Humoral Immunodeficiency: The Relevance of Newborn Screening for Primary Immunodeficiency.

B cell deficiency Zellweger humoral immunodeficiency inborn error of immunity (IEI) metabolic disease newborn screening (NBS) primary immunodeficiency

Journal

Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492

Informations de publication

Date de publication:
2022
Historique:
received: 11 01 2022
accepted: 03 02 2022
entrez: 11 4 2022
pubmed: 12 4 2022
medline: 12 4 2022
Statut: epublish

Résumé

Zellweger syndrome (ZS) is a congenital autosomal recessive disease within the spectrum of peroxisome biogenesis disorders, characterized by the impairment of peroxisome assembly. The presence of peroxisome enzyme deficiencies leads to complex developmental sequelae, progressive disabilities, and multiorgan damage, due to intracellular accumulation of very-long-chain fatty acids (VLCFAs). We report the case of an infant affected by ZS in which agammaglobulinemia, detected through neonatal screening of congenital immunodeficiencies, appeared as a peculiar trait standing out among all the other classical characteristics of the syndrome. The exome analysis through next-generation sequencing (NGS), which had previously confirmed the diagnostic suspicion of ZS, was repeated, but no mutations causative of inborn error of immunity (humoral defect) were detected. In this case, no genetic variants accountable for the abovementioned agammaglobulinemia were detected. Given that the scientific literature reports the involvement of peroxisomes in the activation of Nuclear Factor κ-light-chain-enhancer of activated B cells (NF-κB) pathway, which is crucial for B-cell survival, with this work, we hypothesize the existence of a link between ZS and humoral immunodeficiencies. Further studies are required to confirm this hypothesis.

Sections du résumé

Background UNASSIGNED
Zellweger syndrome (ZS) is a congenital autosomal recessive disease within the spectrum of peroxisome biogenesis disorders, characterized by the impairment of peroxisome assembly. The presence of peroxisome enzyme deficiencies leads to complex developmental sequelae, progressive disabilities, and multiorgan damage, due to intracellular accumulation of very-long-chain fatty acids (VLCFAs).
Case Presentation UNASSIGNED
We report the case of an infant affected by ZS in which agammaglobulinemia, detected through neonatal screening of congenital immunodeficiencies, appeared as a peculiar trait standing out among all the other classical characteristics of the syndrome. The exome analysis through next-generation sequencing (NGS), which had previously confirmed the diagnostic suspicion of ZS, was repeated, but no mutations causative of inborn error of immunity (humoral defect) were detected.
Conclusion UNASSIGNED
In this case, no genetic variants accountable for the abovementioned agammaglobulinemia were detected. Given that the scientific literature reports the involvement of peroxisomes in the activation of Nuclear Factor κ-light-chain-enhancer of activated B cells (NF-κB) pathway, which is crucial for B-cell survival, with this work, we hypothesize the existence of a link between ZS and humoral immunodeficiencies. Further studies are required to confirm this hypothesis.

Identifiants

pubmed: 35402347
doi: 10.3389/fped.2022.852943
pmc: PMC8990230
doi:

Types de publication

Case Reports

Langues

eng

Pagination

852943

Informations de copyright

Copyright © 2022 Fazi, Lodi, Magi, Canessa, Giovannini, Pelosi, Pochiero, Procopio, Donati, Azzari and Ricci.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

C Fazi (C)

Pediatric Immunology Division, Meyer Children's Hospital, Florence, Italy.

L Lodi (L)

Pediatric Immunology Division, Meyer Children's Hospital, Florence, Italy.
Department of Health Sciences, University of Florence, Florence, Italy.

L Magi (L)

Neonatology Division, San Donato Hospital, Arezzo, Italy.

C Canessa (C)

Pediatric Immunology Division, Meyer Children's Hospital, Florence, Italy.

M Giovannini (M)

Pediatric Allergy Division, Meyer Children's Hospital, Florence, Italy.

C Pelosi (C)

Department of Health Sciences, University of Florence, Florence, Italy.

F Pochiero (F)

Department of Metabolic Diseases, Meyer Children's Hospital, Florence, Italy.

E Procopio (E)

Department of Metabolic Diseases, Meyer Children's Hospital, Florence, Italy.

M A Donati (MA)

Department of Metabolic Diseases, Meyer Children's Hospital, Florence, Italy.

C Azzari (C)

Pediatric Immunology Division, Meyer Children's Hospital, Florence, Italy.
Department of Health Sciences, University of Florence, Florence, Italy.

S Ricci (S)

Pediatric Immunology Division, Meyer Children's Hospital, Florence, Italy.
Department of Health Sciences, University of Florence, Florence, Italy.

Classifications MeSH