Successful ex vivo expansion of mouse hematopoietic stem cells.
Ex vivo expansion
Hematopoietic stem cells
Polyvinylalcohol
Self-renewal
Journal
Blood science (Baltimore, Md.)
ISSN: 2543-6368
Titre abrégé: Blood Sci
Pays: United States
ID NLM: 9918248414306676
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
11
06
2019
accepted:
17
06
2019
entrez:
11
4
2022
pubmed:
17
9
2019
medline:
17
9
2019
Statut:
epublish
Résumé
Ex vivo expansion of hematopoietic stem cells (HSCs) is considered the holy grail in stem cell biology and therapy, as it has long been difficult to make this procedure possible. Yamazaki's research team has established new, polyvinyl alcohol-based culture conditions and shown a significant expansion of mouse HSCs from a small number of cells after a month of culture. Surprisingly, expanded HSCs were able to reconstitute unconditioned normal mice. There is generally a technical concern in limiting dilution assay to estimate a fold-expansion of HSCs. But, this work paves the way toward expansion of human HSCs useful for transplantation medicine.
Identifiants
pubmed: 35402802
doi: 10.1097/BS9.0000000000000006
pii: BLS-19-027
pmc: PMC8974897
doi:
Types de publication
Journal Article
Langues
eng
Pagination
116-118Informations de copyright
Copyright © 2019 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Association for Blood Sciences.
Déclaration de conflit d'intérêts
Conflicts of interest: The author declares that he has no conflicts of interest related to the subject matter or materials discussed in this article.
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