DNA methylation in relation to gestational age and brain dysmaturation in preterm infants.
DNA methylation
MRI
brain
development
neonate
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
04
2021
revised:
10
12
2021
accepted:
04
03
2022
entrez:
11
4
2022
pubmed:
12
4
2022
medline:
12
4
2022
Statut:
epublish
Résumé
Preterm birth is associated with dysconnectivity of structural brain networks and is a leading cause of neurocognitive impairment in childhood. Variation in DNA methylation is associated with early exposure to extrauterine life but there has been little research exploring its relationship with brain development. Using genome-wide DNA methylation data from the saliva of 258 neonates, we investigated the impact of gestational age on the methylome and performed functional analysis to identify enriched gene sets from probes that contributed to differentially methylated probes or regions. We tested the hypothesis that variation in DNA methylation could underpin the association between low gestational age at birth and atypical brain development by linking differentially methylated probes with measures of white matter connectivity derived from diffusion MRI metrics: peak width skeletonized mean diffusivity, peak width skeletonized fractional anisotropy and peak width skeletonized neurite density index. Gestational age at birth was associated with widespread differential methylation at term equivalent age, with genome-wide significant associations observed for 8870 CpG probes (
Identifiants
pubmed: 35402911
doi: 10.1093/braincomms/fcac056
pii: fcac056
pmc: PMC8984700
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcac056Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : The Dunhill Medical Trust
ID : R380R/1114
Pays : United Kingdom
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.
Références
Genome Med. 2013 Oct 18;5(10):96
pubmed: 24134860
Transl Psychiatry. 2016 Jan 19;6:e716
pubmed: 26784970
Clin Epigenetics. 2020 Oct 19;12(1):151
pubmed: 33076993
Genome Biol. 2021 Jun 8;22(1):173
pubmed: 34103055
Dev Biol. 2000 Jan 15;217(2):266-77
pubmed: 10625552
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
IEEE Trans Med Imaging. 2010 Jun;29(6):1310-20
pubmed: 20378467
Neurosci Biobehav Rev. 2018 Jan;84:262-271
pubmed: 28867654
Bioinformatics. 2012 Mar 15;28(6):882-3
pubmed: 22257669
Lancet Neurol. 2009 Jan;8(1):110-24
pubmed: 19081519
Eur J Hum Genet. 2013 Nov;21(11):1219-25
pubmed: 23486536
Genome Biol. 2016 Aug 30;17(1):176
pubmed: 27572077
Bioinformatics. 2014 May 15;30(10):1363-9
pubmed: 24478339
PLoS Genet. 2017 Aug 1;13(8):e1006923
pubmed: 28763441
Wellcome Open Res. 2022 Feb 4;7:41
pubmed: 35592546
Eur J Hum Genet. 2019 Apr;27(4):582-593
pubmed: 30622326
Cereb Cortex. 2015 Nov;25(11):4310-8
pubmed: 25596587
J Child Psychol Psychiatry. 2018 Nov;59(11):1192-1200
pubmed: 29667718
Neuroimage. 2016 Jun;133:207-223
pubmed: 26826512
Lancet Glob Health. 2019 Jan;7(1):e37-e46
pubmed: 30389451
Neuroimage. 2016 Nov 15;142:394-406
pubmed: 27523449
Nutrients. 2019 Nov 17;11(11):
pubmed: 31744183
PLoS Med. 2010 Jun 08;7(6):e1000289
pubmed: 20543995
Neuroimage. 2017 Jan;144(Pt B):299-304
pubmed: 26794641
Psychol Med. 2011 Dec;41(12):2463-74
pubmed: 21733218
Magn Reson Med. 2016 Nov;76(5):1582-1593
pubmed: 26599599
Brain Behav Immun. 2020 Nov;90:311-318
pubmed: 32920182
Pediatrics. 2018 Sep;142(3):
pubmed: 30076190
Epigenetics. 2013 Apr;8(4):445-54
pubmed: 23538714
J Mol Neurosci. 2020 Jan;70(1):1-8
pubmed: 31428919
Int J Epidemiol. 2015 Aug;44(4):1288-304
pubmed: 25855720
FASEB J. 2014 May;28(5):2088-97
pubmed: 24478308
Neuroimage. 2017 May 15;152:450-466
pubmed: 28284799
Genome Med. 2020 Mar 2;12(1):25
pubmed: 32114984
Genome Biol. 2017 Jan 27;18(1):19
pubmed: 28129774
Pediatrics. 2018 Jan;141(1):
pubmed: 29255083
Front Psychiatry. 2019 Jul 26;10:524
pubmed: 31402877
Neuroimage. 2019 Nov 15;202:116137
pubmed: 31473352
Neuroimage. 2019 Mar;188:598-615
pubmed: 30537563
Arch Gen Psychiatry. 2012 Jun;69(6):E1-8
pubmed: 22660967
Epigenetics. 2016;11(2):140-9
pubmed: 26889969
Sci Rep. 2019 Apr 19;9(1):6322
pubmed: 31004082
Genome Biol. 2016 Oct 7;17(1):207
pubmed: 27717397
Nat Commun. 2019 Apr 23;10(1):1893
pubmed: 31015461
BMJ Open. 2020 Mar 4;10(3):e035854
pubmed: 32139495
Neuroimage Clin. 2020;25:102195
pubmed: 32044713
Neuroimage. 2004;23 Suppl 1:S208-19
pubmed: 15501092
Development. 2003 Mar;130(6):1037-48
pubmed: 12571096
Transl Psychiatry. 2019 Jan 31;9(1):47
pubmed: 30705257
Neuroimage. 2019 Feb 1;186:321-337
pubmed: 30391562
Neuroimage. 2012 Jul 16;61(4):1000-16
pubmed: 22484410
Hypertension. 2019 Aug;74(2):375-383
pubmed: 31230546
Brain Struct Funct. 2017 Dec;222(9):4023-4033
pubmed: 28589258
Am J Med Genet B Neuropsychiatr Genet. 2015 Jan;168B(1):36-44
pubmed: 25355443
Front Neurol. 2020 Apr 03;11:235
pubmed: 32318015
Magn Reson Med. 2013 Jun;69(6):1534-40
pubmed: 23625329
Dev Genes Evol. 2001 May;211(5):257-60
pubmed: 11455441
Am J Hum Genet. 2012 Feb 10;90(2):260-72
pubmed: 22305529
Placenta. 2020 Apr;93:56-63
pubmed: 32250740
Neuroimage. 2016 Nov 1;141:556-572
pubmed: 27393418
Stem Cells. 2010 Nov;28(11):1950-60
pubmed: 20872847
Genom Data. 2016 May 26;9:22-4
pubmed: 27330998
PLoS Genet. 2007 Sep;3(9):1724-35
pubmed: 17907809
Neurotherapeutics. 2013 Oct;10(4):742-56
pubmed: 24104594
Neurosci Biobehav Rev. 2020 Jun;113:133-156
pubmed: 32151655
Neuroimage. 2016 Jan 15;125:1063-1078
pubmed: 26481672
Nat Rev Genet. 2015 May;16(5):261-75
pubmed: 25732612
Philos Trans R Soc Lond B Biol Sci. 2019 Apr 15;374(1770):20180120
pubmed: 30966880
Front Neurol. 2019 Feb 13;10:81
pubmed: 30814973
Am J Hum Genet. 2016 Apr 7;98(4):680-96
pubmed: 27040690
Epigenomics. 2018 Jul;10(7):925-940
pubmed: 29693419
Neuropathol Appl Neurobiol. 2020 Aug;46(5):413-421
pubmed: 31747472
Arch Dis Child Fetal Neonatal Ed. 2015 Jul;100(4):F301-8
pubmed: 25834170
BMC Genomics. 2013 May 01;14:293
pubmed: 23631413
Genome Res. 2015 Mar;25(3):338-52
pubmed: 25650246
J Pediatr. 2010 Apr;156(4):525-31.e2
pubmed: 20056232
Genet Epidemiol. 2018 Feb;42(1):20-33
pubmed: 29034560
BMC Med. 2021 Feb 5;19(1):42
pubmed: 33541338
Ann Neurol. 2016 Oct;80(4):581-92
pubmed: 27518166
Hum Mol Genet. 2017 Oct 15;26(20):4067-4085
pubmed: 29016858