Odours of cancerous mouse congeners: detection and attractiveness.
Mus musculus domesticus
Body odours
EGFR oncogenic mutation
Female preference
Lung cancer
Odour discrimination
Volatile organic compounds
Journal
Biology open
ISSN: 2046-6390
Titre abrégé: Biol Open
Pays: England
ID NLM: 101578018
Informations de publication
Date de publication:
15 04 2022
15 04 2022
Historique:
received:
23
12
2021
accepted:
31
03
2022
pubmed:
12
4
2022
medline:
3
5
2022
entrez:
11
4
2022
Statut:
ppublish
Résumé
Chemical communication plays a major role in social interactions. Cancer, by inducing changes in body odours, may alter interactions between individuals. In the framework of research targeting non-invasive methods to detect early stages of cancer development, this study asked whether untrained mice could detect odour changes in cancerous congeners. If yes, were they able to detect cancer at an early developmental stage? Did it influence female preference? Did variations in volatile organic components of the odour source paralleled mice behavioural responses? We used transgenic mice strains developing or not lung cancer upon antibiotic ingestion. We sampled soiled bedding of cancerous mice (CC) and not cancerous mice (NC), at three experimental conditions: before (T0), early stage (T2) and late stage (T12) of cancer development. Habituation/generalisation and two-way preference tests were performed where soiled beddings of CC and NC mice were presented to wild-derived mice. The composition and relative concentration of volatile organic components (VOC) in the two stimuli types were analysed. Females did not show directional preference at any of the experimental conditions, suggesting that cancer did not influence their choice behaviour. Males did not discriminate between CC and NC stimuli at T0 but did so at T2 and T12, indicating that wild-derived mice could detect cancer at an early stage of development. Finally, although the VOC bouquet differed between CC and NC it did not seem to parallel the observed behavioural response suggesting that other types of odorant components might be involved in behavioural discrimination between CC and NC mice.
Identifiants
pubmed: 35403195
pii: 275010
doi: 10.1242/bio.059208
pmc: PMC9065363
pii:
doi:
Substances chimiques
Volatile Organic Compounds
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing or financial interests.
Références
Biol Lett. 2011 Dec 23;7(6):807-10
pubmed: 21525047
J Breath Res. 2015 May 06;9(2):027001
pubmed: 25944810
Eur Respir J. 2012 Mar;39(3):669-76
pubmed: 21852337
Arch Immunol Ther Exp (Warsz). 2018 Aug;66(4):245-266
pubmed: 29411049
Sci Rep. 2015 Jul 02;5:11805
pubmed: 26133466
Vet Clin North Am Exot Anim Pract. 2004 Sep;7(3):627-51, vi
pubmed: 15296867
Trends Ecol Evol. 2013 Nov;28(11):628-35
pubmed: 23972467
Steroids. 2014 May;83:10-6
pubmed: 24525008
Lab Anim Sci. 1979 Oct;29(5):645-51
pubmed: 92595
Trends Ecol Evol. 2008 Apr;23(4):220-8
pubmed: 18308422
Sci Adv. 2017 Apr 07;3(4):e1601721
pubmed: 28435875
Thorax. 2012 May;67(5):412-7
pubmed: 22052579
Behav Brain Res. 2009 Jun 25;200(2):295-303
pubmed: 19146884
Trends Parasitol. 2005 Sep;21(9):423-9
pubmed: 16043413
Behav Processes. 2005 Mar 31;68(3):185-99
pubmed: 15792688
Evol Appl. 2013 Jan;6(1):144-59
pubmed: 23396885
Parasitol Today. 1991 Dec;7(12):329-34
pubmed: 15463407
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2010 Oct;196(10):685-700
pubmed: 20680632
Trends Neurosci. 2006 Nov;29(11):604-9
pubmed: 16904761
Nat Ecol Evol. 2017 Nov;1(11):1592-1595
pubmed: 29066812
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2010 Oct;196(10):713-27
pubmed: 20526605
Sci Rep. 2017 Nov 7;7(1):14628
pubmed: 29116175
EMBO Rep. 2013 Aug;14(8):686-95
pubmed: 23846313
J Clin Invest. 2020 Feb 3;130(2):612-624
pubmed: 31671073
Toxicol Pathol. 1993;21(2):206-18
pubmed: 8210943
Exp Anim. 2001 Apr;50(2):99-103
pubmed: 11381627
Seizure. 2000 Sep;9(6):427-30
pubmed: 10986001
Vet Clin North Am Exot Anim Pract. 2013 May;16(2):383-406
pubmed: 23642868
Thorax. 2011 Sep;66(9):804-9
pubmed: 21749985
J Natl Cancer Inst. 1962 May;28:1153-63
pubmed: 13861336
Cancer Cell. 2007 Jul;12(1):81-93
pubmed: 17613438
J Biomark. 2015;2015:841245
pubmed: 26317038
Trans R Soc Trop Med Hyg. 2002 Mar-Apr;96(2):117-8
pubmed: 12055795
Science. 1973 Nov 20;182(4115):939-41
pubmed: 4745598
Bioessays. 2004 Dec;26(12):1288-98
pubmed: 15551272
J Proteome Res. 2010 Mar 5;9(3):1627-34
pubmed: 20121166
Nat Rev Cancer. 2003 Mar;3(3):226-31
pubmed: 12612657
J Vet Med Sci. 1996 Sep;58(9):933-5
pubmed: 8898298
J Proteome Res. 2020 May 1;19(5):1913-1922
pubmed: 32227867
Clin Chem. 2013 Jan;59(1):168-79
pubmed: 23220226
Biochim Biophys Acta Rev Cancer. 2022 Jan;1877(1):188644
pubmed: 34737023
J Exp Biol. 2010 May;213(Pt 9):1399-405
pubmed: 20400623
BMC Infect Dis. 2020 Jul 23;20(1):536
pubmed: 32703188
Proc Biol Sci. 2013 Dec 18;281(1776):20132733
pubmed: 24352947
Proc Natl Acad Sci U S A. 2018 May 29;115(22):5780-5785
pubmed: 29760095
Behav Res Methods. 2007 May;39(2):175-91
pubmed: 17695343
Physiol Behav. 1998 Jun 1;64(3):235-43
pubmed: 9748088
Parasitology. 2002 Nov;125(Pt 5):461-6
pubmed: 12458830
Chem Senses. 2010 May;35(4):309-21
pubmed: 20190009
Cancer Cell Int. 2012 Feb 24;12(1):7
pubmed: 22364569
Clin Chim Acta. 2004 Jun;344(1-2):189-94
pubmed: 15149888
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2010 Oct;196(10):751-66
pubmed: 20490809
Sci Rep. 2014 Jan 06;4:3576
pubmed: 24389870
J Chem Ecol. 2018 Mar;44(3):215-234
pubmed: 29479643
PLoS One. 2010 Jan 27;5(1):e8819
pubmed: 20111698
Prog Exp Tumor Res. 1983;26:241-58
pubmed: 6844643