Tissue chaperoning-the expanded functions of fetuin-A beyond inhibition of systemic calcification.
Biomineralization
Fetuin-A
Inflammation
Kidney injury
Mineral chaperone
Journal
Pflugers Archiv : European journal of physiology
ISSN: 1432-2013
Titre abrégé: Pflugers Arch
Pays: Germany
ID NLM: 0154720
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
24
02
2022
accepted:
31
03
2022
revised:
29
03
2022
pubmed:
12
4
2022
medline:
3
8
2022
entrez:
11
4
2022
Statut:
ppublish
Résumé
Traditionally, fetuin-A embodies the prototype anti-calcification protein in the blood, preventing cardiovascular calcification. Low serum fetuin-A is generally associated with mineralization dysbalance and enhanced mortality in end stage renal disease. Recent evidence indicates that fetuin-A is a crucial factor moderating tissue inflammation and fibrosis, as well as a systemic indicator of acute inflammatory disease. Here, the expanded function of fetuin-A is discussed in the context of mineralization and inflammation biology. Unbalanced depletion of fetuin-A in this context may be the critical event, triggering a vicious cycle of progressive calcification, inflammation, and tissue injury. Hence, we designate fetuin-A as tissue chaperone and propose the potential use of exogenous fetuin-A as prophylactic agent or emergency treatment in conditions that are associated with acute depletion of endogenous protein.
Identifiants
pubmed: 35403906
doi: 10.1007/s00424-022-02688-6
pii: 10.1007/s00424-022-02688-6
pmc: PMC8995415
doi:
Substances chimiques
alpha-2-HS-Glycoprotein
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
949-962Informations de copyright
© 2022. The Author(s).
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