Comparison of absorbed dose extrapolation methods for mouse-to-human translation of radiolabelled macromolecules.
Allometric equations
Biodistribution
Dose extrapolations
Mass scaling
Metabolic time scaling
OLINDA/EXM® 2.0
Preclinical models
Radiopharmaceuticals
Scaling factor
Small animal dosimetry
Journal
EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946
Informations de publication
Date de publication:
11 Apr 2022
11 Apr 2022
Historique:
received:
17
01
2022
accepted:
26
03
2022
entrez:
11
4
2022
pubmed:
12
4
2022
medline:
12
4
2022
Statut:
epublish
Résumé
Extrapolation of human absorbed doses (ADs) from biodistribution experiments on laboratory animals is used to predict the efficacy and toxicity profiles of new radiopharmaceuticals. Comparative studies between available animal-to-human dosimetry extrapolation methods are missing. We compared five computational methods for mice-to-human AD extrapolations, using two different radiopharmaceuticals, namely [ For both radiopharmaceuticals, the five extrapolation methods showed significantly different AD results (p < 0.0001). In general, organ ADs obtained with M3 were higher than those obtained with the other methods. For [ Available methods for mouse-to-human dosimetry extrapolations provided significantly different results in two different experimental models. For [
Sections du résumé
BACKGROUND
BACKGROUND
Extrapolation of human absorbed doses (ADs) from biodistribution experiments on laboratory animals is used to predict the efficacy and toxicity profiles of new radiopharmaceuticals. Comparative studies between available animal-to-human dosimetry extrapolation methods are missing. We compared five computational methods for mice-to-human AD extrapolations, using two different radiopharmaceuticals, namely [
RESULTS
RESULTS
For both radiopharmaceuticals, the five extrapolation methods showed significantly different AD results (p < 0.0001). In general, organ ADs obtained with M3 were higher than those obtained with the other methods. For [
CONCLUSIONS
CONCLUSIONS
Available methods for mouse-to-human dosimetry extrapolations provided significantly different results in two different experimental models. For [
Identifiants
pubmed: 35403982
doi: 10.1186/s13550-022-00893-z
pii: 10.1186/s13550-022-00893-z
pmc: PMC9001797
doi:
Types de publication
Journal Article
Langues
eng
Pagination
21Subventions
Organisme : Horizon 2020
ID : (642889 MEDICIS-PROMED)
Informations de copyright
© 2022. The Author(s).
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