The Ketamine Side Effect Tool (KSET): A comprehensive measurement-based safety tool for ketamine treatment in psychiatry.


Journal

Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073

Informations de publication

Date de publication:
01 07 2022
Historique:
received: 23 09 2021
revised: 01 03 2022
accepted: 06 04 2022
pubmed: 12 4 2022
medline: 25 5 2022
entrez: 11 4 2022
Statut: ppublish

Résumé

On a background of the rapidly expanding clinical use of ketamine and esketamine for treatment of depression and other conditions, we examined safety monitoring, seeking to identify knowledge gaps relevant to clinical practice. An international group of psychiatrists discussed the issue of safety of ketamine and esketamine and came to a consensus on key safety gaps. There is no standard safety monitoring for off-label generic ketamine. For intranasal esketamine, each jurisdiction providing regulatory approval may specify monitoring. Treatment is often provided beyond the period for which safety has been demonstrated, with no agreed framework for monitoring of longer term side effects for either generic ketamine or intranasal esketamine. The KSET has established face and content validity, however it has not been validated against other measures of safety. We recommend the Ketamine Side Effect Tool (KSET) as a comprehensive safety monitoring tool for acute and longer term side effects.

Identifiants

pubmed: 35405177
pii: S0165-0327(22)00357-3
doi: 10.1016/j.jad.2022.04.020
pmc: PMC9133168
mid: NIHMS1798675
pii:
doi:

Substances chimiques

Antidepressive Agents 0
Ketamine 690G0D6V8H

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

44-46

Subventions

Organisme : Intramural NIH HHS
ID : ZIA MH002857
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

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Auteurs

Adam Bayes (A)

Black Dog Institute, UNSW Sydney, Australia; School of Psychiatry, UNSW Sydney, Australia. Electronic address: a.bayes@unsw.edu.au.

Brooke Short (B)

St Vincent's Hospital, Sydney, Australia.

Carlos A Zarate (CA)

Division of Intramural Research Program, National Institute of Mental Health, MD, United States.

Lawrence Park (L)

Division of Intramural Research Program, National Institute of Mental Health, MD, United States.

James W Murrough (JW)

Depression and Anxiety Centre for Discovery and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Declan M McLoughlin (DM)

Department of Psychiatry, Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.

Patricio Riva-Posse (P)

Department of Psychiatry and Behavioral Sciences at Emory University, Atlanta, GA, United States.

Robert Schoevers (R)

The University Medical Center Groningen, Groningen, the Netherlands.

Jolien Veraart (J)

The University Medical Center Groningen, Groningen, the Netherlands.

Sagar Parikh (S)

Department of Psychiatry, University of Michigan, MI, United States.

Paul Glue (P)

University of Otago, Dunedin, New Zealand.

Johnson Fam (J)

Department of Psychological Medicine, National University Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Rupert McShane (R)

Department of Psychiatry, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.

Veronica Galvez (V)

Corporacio Sanitaria Parc Tauli, Universitat Autonoma de Barcelona, I3PT, Institut d'Investigacio i Innovacio Parc Tauli, Sabadell, Barcelona, Spain.

Donel Martin (D)

Black Dog Institute, UNSW Sydney, Australia.

Phern-Chern Tor (PC)

Institute of Mental Health, Singapore.

Andre R Brunoni (AR)

Laboratory of Neurosciences (LIM-27), Institute of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da USP, Brazil.

Colleen K Loo (CK)

Black Dog Institute, UNSW Sydney, Australia; School of Psychiatry, UNSW Sydney, Australia.

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Classifications MeSH