Placental pathology from COVID-19-recovered (nonacute) patients.
COVID-19
Fetal vascular malperfusion
Maternal vascular malperfusion
Placenta
SARSp-CoV-2
Journal
Human pathology
ISSN: 1532-8392
Titre abrégé: Hum Pathol
Pays: United States
ID NLM: 9421547
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
07
03
2022
revised:
01
04
2022
accepted:
04
04
2022
pubmed:
12
4
2022
medline:
15
6
2022
entrez:
11
4
2022
Statut:
ppublish
Résumé
Placental pathology can identify characteristic features of specific infectious pathogens. The histopathology of acute SARS-CoV-2 placental infection and exposure without infection has been well described. However, whether the characteristic placental pathology persists after the acute phase of the infection is less clear. We retrospectively identified 67 COVID-19-recovered pregnant patients who had placental pathology available. After reviewing the gross and histopathology, we categorized the findings and studied the placentas for evidence of chronic infection by immunohistochemistry for the spike protein of the virus. We found these placentas showed significantly increased prevalence of maternal and a trend towards significance of fetal vascular malperfusion when compared to a control group of placentas examined for the sole indication of maternal group B streptococcal colonization. None of the COVID-19-recovered placentas showed expression of the viral spike protein; therefore, we found no evidence of persistent infection of the placenta in women with a history of COVID-19 during their pregnancy. We conclude that recovery from a SARS-CoV-2 infection during pregnancy puts the pregnancy at risk for specific pathology.
Identifiants
pubmed: 35405186
pii: S0046-8177(22)00084-3
doi: 10.1016/j.humpath.2022.04.005
pmc: PMC8993452
pii:
doi:
Substances chimiques
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
18-22Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Références
Am J Obstet Gynecol MFM. 2020 Nov;2(4):100211
pubmed: 32838277
Arch Pathol Lab Med. 2021 Jun 1;145(6):648-656
pubmed: 33596304
Eur J Obstet Gynecol Reprod Biol. 2021 Apr;259:7-11
pubmed: 33556768
APMIS. 2018 Jul;126(7):561-569
pubmed: 30129125
Arch Pathol Lab Med. 2021 Nov 1;145(11):1341-1349
pubmed: 34338723
Am J Obstet Gynecol. 2021 Apr;224(4):382.e1-382.e18
pubmed: 33091406
Pathobiology. 2021;88(1):69-77
pubmed: 32950981
Am J Clin Pathol. 2021 Jul 6;156(2):329-330
pubmed: 34145875
Am J Clin Pathol. 2020 Jun 8;154(1):23-32
pubmed: 32441303
BJOG. 2020 Nov;127(12):1548-1556
pubmed: 32633022
Arch Pathol Lab Med. 2021 May 1;145(5):517-528
pubmed: 33393592
Mod Pathol. 2020 Nov;33(11):2092-2103
pubmed: 32741970
Am J Surg Pathol. 2022 Jan 1;46(1):51-57
pubmed: 34310367
Pediatr Dev Pathol. 2020 May-Jun;23(3):177-180
pubmed: 32397896
J Infect Dis. 2022 Mar 2;225(5):754-758
pubmed: 35024844
Am J Obstet Gynecol. 2021 Dec;225(6):593.e1-593.e9
pubmed: 34364845
Arch Pathol Lab Med. 2016 Jul;140(7):698-713
pubmed: 27223167
Placenta. 2020 Nov;101:13-29
pubmed: 32911234
APMIS. 2018 Jul;126(7):551-560
pubmed: 30129127
JAMA Netw Open. 2022 Mar 1;5(3):e225345
pubmed: 35311965