Klebsiella species: Taxonomy, hypervirulence and multidrug resistance.

Anti-Bacterial Agents / pharmacology Bacterial Proteins / genetics Drug Resistance, Multiple, Bacterial Klebsiella / classification Klebsiella pneumoniae Plasmids
Convergence Evolution Hypervirulence Klebsiella spp. Multidrug resistance Taxonomy

Journal

EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039

Informations de publication

Date de publication:
May 2022
Historique:
received: 24 10 2021
revised: 25 03 2022
accepted: 28 03 2022
pubmed: 12 4 2022
medline: 18 5 2022
entrez: 11 4 2022
Statut: ppublish

Résumé

Members of the genus Klebsiella have rapidly evolved within the past decade, generating organisms that simultaneously exhibit both multidrug resistance and hypervirulence (MDR-hv) phenotypes; such organisms are associated with severe hospital- and community-acquired infections. Carbapenem-resistant infections with unknown optimal treatment regime were of particular concern among the MDR-hv Klebsiella strains. Recent studies have revealed the molecular features and the mobile resistance elements they harbour, allowing identification of genetic loci responsible for transmission, stable inheritance, and expression of mobile resistance or virulence-encoding elements that confer the new phenotypic characteristics of MDR-hv Klebsiella spp. Here, we provide a comprehensive review on the taxonomic position, species composition and different phylotypes of Klebsiella spp., describing the diversity and worldwide distribution of the MDR-hv clones, the genetic mutation and horizontal gene transfer events that drive the evolution of such clones, and the potential impact of MDR-hv infections on human health.

Identifiants

DOI: 10.1016/j.ebiom.2022.103998 PMID: 35405387 PMC: PMC9010751
pubmed: 35405387
pii: S2352-3964(22)00182-7
doi: 10.1016/j.ebiom.2022.103998
pmc: PMC9010751
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Bacterial Proteins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

103998

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests All authors declare that they have no competing interests.

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Auteurs

Ning Dong (N)

Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong, China.

Xuemei Yang (X)

Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong, China.

Edward Wai-Chi Chan (EW)

State Key Lab of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong polytechnic University, Hung Hom, Hong Kong, China.

Rong Zhang (R)

Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang, Hangzhou, China.

Sheng Chen (S)

Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong, China. Electronic address: shechen@cityu.edu.hk.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Klebsiella species: Taxonomy, hypervirulence...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Klebsiella species: Taxonomy, hypervirulence...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Multirésistance aux médicaments › Multirésistance bactérienne aux médicaments › Klebsiella species: Taxonomy, hypervirulence...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Klebsiella › Klebsiella species: Taxonomy, hypervirulence...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Klebsiella › Klebsiella pneumoniae › Klebsiella species: Taxonomy, hypervirulence...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Plasmides › Klebsiella species: Taxonomy, hypervirulence...