Patterning of brain organoids derived from human pluripotent stem cells.

Brain Humans Organoids Pluripotent Stem Cells

Journal

Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376

Informations de publication

Date de publication:
06 2022
Historique:
received: 08 11 2021
revised: 27 02 2022
accepted: 03 03 2022
pubmed: 12 4 2022
medline: 7 6 2022
entrez: 11 4 2022
Statut: ppublish

Résumé

The emerging technology of brain organoids deriving from human pluripotent stem cells provides unprecedented opportunities to study human brain development and associated disorders. Various brain organoid protocols have been developed that can recapitulate some key features of cell type diversity, cytoarchitectural organization, developmental processes, functions, and pathologies of the developing human brain. In this review, we focus on patterning of human stem cell-derived brain organoids. We start with an overview of general procedures to generate brain organoids. We then highlight some recently developed brain organoid protocols and chemical cues involved in modeling development of specific human brain regions, subregions, and multiple regions together. We also discuss limitations and potential future improvements of human brain organoid technology.

Identifiants

DOI: 10.1016/j.conb.2022.102536 PMID: 35405627 PMC: PMC9167774
pubmed: 35405627
pii: S0959-4388(22)00030-7
doi: 10.1016/j.conb.2022.102536
pmc: PMC9167774
mid: NIHMS1797217
pii:
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

102536

Subventions

Organisme : NINDS NIH HHS
ID : R35 NS097370
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH123979
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH125528
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI131130
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS116843
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH105128
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest statement Nothing declared.

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Auteurs

Zhijian Zhang (Z)

Department of Neuroscience and Mahoney Institute for Neurosciences, Philadelphia, PA 19104, USA.

Richard O'Laughlin (R)

Department of Neuroscience and Mahoney Institute for Neurosciences, Philadelphia, PA 19104, USA.

Hongjun Song (H)

Department of Neuroscience and Mahoney Institute for Neurosciences, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Philadelphia, PA 19104, USA; The Epigenetics Institute, Philadelphia, PA 19104, USA. Electronic address: https://twitter.com/UPenn_SongMing.

Guo-Li Ming (GL)

Department of Neuroscience and Mahoney Institute for Neurosciences, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Philadelphia, PA 19104, USA; Department of Psychiatry, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: gming@pennmedicine.upenn.edu.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Patterning of brain organoids derived from...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Patterning of brain organoids derived from...
questionsmedicales.fr › Tissus › Organoïdes › Patterning of brain organoids derived from...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Patterning of brain organoids derived from...