Recent Strategies for the Immobilization of Therapeutic Enzymes.
adsorption
carrier
covalent attachment
entrapment
immobilization
protein engineering
therapeutic enzyme
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
30 Mar 2022
30 Mar 2022
Historique:
received:
25
02
2022
revised:
18
03
2022
accepted:
23
03
2022
entrez:
12
4
2022
pubmed:
13
4
2022
medline:
13
4
2022
Statut:
epublish
Résumé
Therapeutic enzymes play important roles in modern medicine due to their high affinity and specificity. However, it is very expensive to use them in clinical medicine because of their low stability and bioavailability. To improve the stability and effectiveness of therapeutic enzymes, immobilization techniques have been employed to enhance the applications of therapeutic enzymes in the past few years. Reported immobilization techniques include entrapment, adsorption, and covalent attachment. In addition, protein engineering is often used to improve enzyme properties; however, all methods present certain advantages and limitations. For carrier-bound immobilization, the delivery and release of the immobilized enzyme depend on the properties of the carrier and enzyme. In this review, we summarize the advantages and challenges of the current strategies developed to deliver therapeutic enzymes and provide a future perspective on the immobilization technologies used for therapeutic enzyme delivery.
Identifiants
pubmed: 35406282
pii: polym14071409
doi: 10.3390/polym14071409
pmc: PMC9003532
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Research Foundation of Korea
ID : 2019R1C1C11009766
Organisme : National Research Foundation of Korea
ID : 2020R1A4A2002854
Organisme : National Research Foundation of Korea
ID : 2021M3A9I5023254
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