Impaired Terminal Erythroid Maturation in β

erythropoiesis hemoglobin mitochondria reticulocyte β-thalassemia

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
22 Mar 2022
Historique:
received: 13 02 2022
revised: 15 03 2022
accepted: 18 03 2022
entrez: 12 4 2022
pubmed: 13 4 2022
medline: 13 4 2022
Statut: epublish

Résumé

Anemia in β-thalassemia is associated with ineffective erythropoiesis and a shortened lifespan of erythroid cells. The limited differentiation of β-thalassemic erythroblasts has been documented, but the characteristic feature of terminal erythroid maturation and its physiological relevance are not clearly described in β-thalassemias. Here, the red blood cell and reticulocyte cellular characteristics were determined in patients with β

Identifiants

pubmed: 35407362
pii: jcm11071755
doi: 10.3390/jcm11071755
pmc: PMC8999960
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Thunwarat Suriyun (T)

Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Pranee Winichagoon (P)

Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhonpathom 73170, Thailand.

Suthat Fucharoen (S)

Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhonpathom 73170, Thailand.

Orapan Sripichai (O)

Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhonpathom 73170, Thailand.
National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand.

Classifications MeSH