Effect of MAO-B Inhibitors on Neurometabolic Profile of Patients Affected by Parkinson Disease: A Proton Magnetic Resonance Spectroscopy Study.

MAO-B inhibitors N-acetylaspartate Parkinson’s disease cerebral cortex choline disease progression neurometabolites proton magnetic resonance spectroscopy rasagiline selegiline

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
30 Mar 2022
Historique:
received: 09 02 2022
revised: 18 03 2022
accepted: 27 03 2022
entrez: 12 4 2022
pubmed: 13 4 2022
medline: 13 4 2022
Statut: epublish

Résumé

Parkinson's Disease (PD) is the most common neurodegenerative movement disorder whose treatment is symptomatic. No suitable methods for assessing the effects of dopaminergic drugs on disease progression in clinical trials have yet been provided. The aim of this longitudinal study is to evaluate the influence of rasagiline and selegiline on neurometabolic profile in de novo PD patients by using Proton Magnetic Resonance Spectroscopy (

Identifiants

pubmed: 35407539
pii: jcm11071931
doi: 10.3390/jcm11071931
pmc: PMC8999805
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Italian Health Minister
ID : GR-2013-02359069

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Auteurs

Lilla Bonanno (L)

Neuroimaging Laboratory, IRCCS Centro Neurolesi Bonino-Pulejo, 98124 Messina, Italy.

Rosella Ciurleo (R)

Neuroimaging Laboratory, IRCCS Centro Neurolesi Bonino-Pulejo, 98124 Messina, Italy.

Silvia Marino (S)

Neuroimaging Laboratory, IRCCS Centro Neurolesi Bonino-Pulejo, 98124 Messina, Italy.

Claudio Ruvolo (C)

Neuroimaging Laboratory, IRCCS Centro Neurolesi Bonino-Pulejo, 98124 Messina, Italy.

Rosa Morabito (R)

Neuroimaging Laboratory, IRCCS Centro Neurolesi Bonino-Pulejo, 98124 Messina, Italy.

Alessia Bramanti (A)

Department of Medicine Surgery and Dentistry 'Salerno Medical School', University of Salerno, 84084 Fisciano, Italy.

Francesco Corallo (F)

Neuroimaging Laboratory, IRCCS Centro Neurolesi Bonino-Pulejo, 98124 Messina, Italy.

Classifications MeSH