Sperm Physiological Response to Female Serum-Potential New Insights into the Reproductive Incompatibility Diagnostics.
MHC
cryptic female choice
egg donor
fertilization
genetic compatibility
infertility
sexual selection
sperm function
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Mar 2022
22 Mar 2022
Historique:
received:
02
02
2022
revised:
07
03
2022
accepted:
19
03
2022
entrez:
12
4
2022
pubmed:
13
4
2022
medline:
14
4
2022
Statut:
epublish
Résumé
Infertility is assumed to arise exclusively from male- and female-dependent pathological factors. However, recent studies have indicated that reproductive failure may also result from the reproductive incompatibility of the partners. Selection against such incompatibilities likely occurs via female-derived reproductive secretions, including follicular fluid (FF), that mediate gamete-level mate choice towards the sperm of specific males. To facilitate potential development of diagnostic tests for human reproductive incompatibility, we examined whether sperm physiological response to female serum indicate male-female compatibility in the presence of FF. We performed a full-factorial experiment, in which the sperm of 10 males were treated with the FF and serum of 6 healthy females. We found that sperm motility and viability in both biofluids were highly similar and that in 70% of the males, sperm serum treatment predicted male-female compatibility. We also identified male human leucocyte antigen (HLA) alleles and female (FF and serum) anti-HLA antibodies and tested whether the number of allele-antibody matches predict sperm physiological response to female fluids. However, no association was found between measured sperm traits and the number of allele-antibody matches. Overall, the present results may open novel possibilities for the future development of reproductive incompatibility tests and may pave the way towards more accurate infertility diagnostics and treatments.
Identifiants
pubmed: 35408797
pii: ijms23073428
doi: 10.3390/ijms23073428
pmc: PMC8998597
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Academy of Finland
ID : 327509
Organisme : Academy of Finland
ID : 335567
Organisme : Academy of Finland
ID : 308485
Références
Arch Androl. 2000 Nov-Dec;45(3):203-13
pubmed: 11111869
Hum Reprod Update. 1998 Nov-Dec;4(6):776-86
pubmed: 10098469
PeerJ. 2015 Jul 21;3:e1114
pubmed: 26244118
Trends Ecol Evol. 2017 May;32(5):368-382
pubmed: 28318651
J Reprod Immunol. 2010 Dec;87(1-2):67-73
pubmed: 20605049
Heredity (Edinb). 1996 Oct;77 ( Pt 4):400-9
pubmed: 8885381
Proc Biol Sci. 2020 Aug 26;287(1933):20201682
pubmed: 32811307
Cell Mol Life Sci. 2008 Nov;65(21):3446-57
pubmed: 18622578
Hum Reprod Update. 2001 Mar-Apr;7(2):113-34
pubmed: 11284658
Hum Reprod Update. 2015 Nov-Dec;21(6):711-26
pubmed: 26386468
Animals (Basel). 2020 Dec 30;11(1):
pubmed: 33396764
Reproduction. 2010 Feb;139(2):309-18
pubmed: 19786400
Mol Hum Reprod. 2015 Jun;21(6):491-501
pubmed: 25753084
Am J Reprod Immunol. 1984 Jun;5(4):179-81
pubmed: 6542320
Front Mol Biosci. 2016 Jan 07;2:73
pubmed: 26779489
Mol Ecol. 2015 Aug;24(16):4286-95
pubmed: 25940673
Reproduction. 2005 Dec;130(6):917-21
pubmed: 16322551
Cell Tissue Res. 2005 Oct;322(1):43-52
pubmed: 15909166
Evolution. 2017 Feb;71(2):238-248
pubmed: 27921298
Reprod Biomed Online. 2012 Jun;24(6):591-602
pubmed: 22503948
Front Biosci (Landmark Ed). 2014 Jan 01;19(2):291-303
pubmed: 24389185
Heredity (Edinb). 2020 Nov;125(5):281-289
pubmed: 32747723
Mol Ecol. 2017 Jan;26(2):668-688
pubmed: 27859823
Proc Biol Sci. 2016 Mar 30;283(1827):20160001
pubmed: 27009221
J Cell Physiol. 2006 Nov;209(2):353-62
pubmed: 16883595
Hum Reprod. 2017 Oct 1;32(10):1995-2006
pubmed: 28938737
Proc Biol Sci. 2018 Jul 18;285(1883):
pubmed: 30051836
Mol Genet Genomic Med. 2019 Dec;7(12):e1005
pubmed: 31625276
Ecol Evol. 2016 Jan 30;6(5):1363-77
pubmed: 26855769
Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2840-4
pubmed: 2011591
Sci Rep. 2015 Oct 16;5:15321
pubmed: 26470849
Evolution. 2018 Nov;72(11):2478-2490
pubmed: 30246285
Fertil Steril. 1994 Dec;62(6):1234-7
pubmed: 7957990
Hum Reprod Update. 2017 Nov 1;23(6):646-659
pubmed: 28981654
Proc Biol Sci. 2013 Sep 04;280(1769):20131296
pubmed: 24004935
Hum Reprod. 2021 Nov 18;36(12):3028-3035
pubmed: 34580729
Hum Reprod. 2006 Mar;21(3):728-34
pubmed: 16253967
Proc Biol Sci. 2020 Jun 10;287(1928):20200805
pubmed: 32517615
Reproduction. 2021 Sep 06;162(4):R55-R71
pubmed: 34338216
Comp Biochem Physiol Comp Physiol. 1994 Feb;107(2):277-82
pubmed: 7907959
Am J Reprod Immunol. 1993 Aug;30(1):9-14
pubmed: 8260024
Biol Reprod. 1998 Mar;58(3):705-11
pubmed: 9510957
Proc Biol Sci. 2011 Aug 22;278(1717):2495-501
pubmed: 21227973
Hum Reprod. 2005 Mar;20(3):761-7
pubmed: 15591080
Nat Rev Mol Cell Biol. 2006 Apr;7(4):276-85
pubmed: 16607290
Hum Reprod. 2006 Nov;21(11):2960-8
pubmed: 16893915
Cells. 2019 Mar 19;8(3):
pubmed: 30893784
Am J Pathol. 2019 Oct;189(10):2036-2045
pubmed: 31369754
Hum Reprod. 2003 Jun;18(6):1259-64
pubmed: 12773456
Pharmacogenomics J. 2014 Apr;14(2):192-200
pubmed: 23712092
Adv Exp Med Biol. 2012;763:186-92
pubmed: 23397625
Reprod Biol Endocrinol. 2019 Nov 7;17(1):90
pubmed: 31699106
Biol Reprod. 1996 Sep;55(3):620-9
pubmed: 8862780
NAR Genom Bioinform. 2020 May 06;2(2):lqaa030
pubmed: 33575586
Nat Commun. 2016 Aug 16;7:12452
pubmed: 27529581
J Evol Biol. 2021 Jul;34(7):1125-1132
pubmed: 34056789
Fertil Steril. 1971 Jun;22(6):367-72
pubmed: 4996712