Host and Viral Zinc-Finger Proteins in COVID-19.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
28 Mar 2022
Historique:
received: 31 01 2022
revised: 24 03 2022
accepted: 25 03 2022
entrez: 12 4 2022
pubmed: 13 4 2022
medline: 14 4 2022
Statut: epublish

Résumé

An unprecedented effort to tackle the ongoing COVID-19 pandemic has characterized the activity of the global scientific community over the last two years. Hundreds of published studies have focused on the comprehension of the immune response to the virus and on the definition of the functional role of SARS-CoV-2 proteins. Proteins containing zinc fingers, both belonging to SARS-CoV-2 or to the host, play critical roles in COVID-19 participating in antiviral defenses and regulation of viral life cycle. Differentially expressed zinc finger proteins and their distinct activities could thus be important in determining the severity of the disease and represent important targets for drug development. Therefore, we here review the mechanisms of action of host and viral zinc finger proteins in COVID-19 as a contribution to the comprehension of the disease and also highlight strategies for therapeutic developments.

Identifiants

pubmed: 35409070
pii: ijms23073711
doi: 10.3390/ijms23073711
pmc: PMC8998646
pii:
doi:

Substances chimiques

Antiviral Agents 0
Zinc J41CSQ7QDS

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : University of Campania "Luigi Vanvitelli"
ID : V:ALERE (VAnviteLli pEr la RicErca) program

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Auteurs

Sabrina Esposito (S)

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università della Campania, Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.

Gianluca D'Abrosca (G)

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università della Campania, Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.

Anna Antolak (A)

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università della Campania, Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.

Paolo Vincenzo Pedone (PV)

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università della Campania, Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.

Carla Isernia (C)

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università della Campania, Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.

Gaetano Malgieri (G)

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università della Campania, Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.

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Classifications MeSH