Endogenous Opioids and Their Role in Stem Cell Biology and Tissue Rescue.
endogenous opioid peptides
opioid receptors
proliferation
stem cell differentiation
stem cells
stress response
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Mar 2022
30 Mar 2022
Historique:
received:
08
03
2022
revised:
28
03
2022
accepted:
29
03
2022
entrez:
12
4
2022
pubmed:
13
4
2022
medline:
14
4
2022
Statut:
epublish
Résumé
Opioids are considered the oldest drugs known by humans and have been used for sedation and pain relief for several centuries. Nowadays, endogenous opioid peptides are divided into four families: enkephalins, dynorphins, endorphins, and nociceptin/orphanin FQ. They exert their action through the opioid receptors (ORs), transmembrane proteins belonging to the super-family of G-protein-coupled receptors, and are expressed throughout the body; the receptors are the δ opioid receptor (DOR), μ opioid receptor (MOR), κ opioid receptor (KOR), and nociceptin/orphanin FQ receptor (NOP). Endogenous opioids are mainly studied in the central nervous system (CNS), but their role has been investigated in other organs, both in physiological and in pathological conditions. Here, we revise their role in stem cell (SC) biology, since these cells are a subject of great scientific interest due to their peculiar features and their involvement in cell-based therapies in regenerative medicine. In particular, we focus on endogenous opioids' ability to modulate SC proliferation, stress response (to oxidative stress, starvation, or damage following ischemia-reperfusion), and differentiation towards different lineages, such as neurogenesis, vasculogenesis, and cardiogenesis.
Identifiants
pubmed: 35409178
pii: ijms23073819
doi: 10.3390/ijms23073819
pmc: PMC8998234
pii:
doi:
Substances chimiques
Analgesics, Opioid
0
Opioid Peptides
0
Receptors, Opioid
0
Receptors, Opioid, kappa
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : ELDOR LAB, via Vittor Pisani 16, 20124 Milan, Italy
ID : no grant number
Organisme : DI BELLA FOUNDATION, Via Guglielmo Marconi 51, 40122 Bologna, Italy
ID : no grant number
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