BECLIN1 Is Essential for Podocyte Secretory Pathways Mediating VEGF Secretion and Podocyte-Endothelial Crosstalk.

Animals Beclin-1 / genetics Glomerular Filtration Barrier / metabolism Mice Podocytes / metabolism Secretory Pathway Vascular Endothelial Growth Factor A / genetics
BECLIN1 Golgi network VEGF autophagy glomerulosclerosis podocyte secretory pathway

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
30 Mar 2022
Historique:
received: 23 02 2022
revised: 17 03 2022
accepted: 29 03 2022
entrez: 12 4 2022
pubmed: 13 4 2022
medline: 14 4 2022
Statut: epublish

Résumé

Vascular endothelial growth factor A (VEGFA) secretion from podocytes is crucial for maintaining endothelial integrity within the glomerular filtration barrier. However, until now, the molecular mechanisms underlying podocyte secretory function remained unclear. Through podocyte-specific deletion of BECLIN1 (

Identifiants

DOI: 10.3390/ijms23073825 PMID: 35409185 PMC: PMC8998849
pubmed: 35409185
pii: ijms23073825
doi: 10.3390/ijms23073825
pmc: PMC8998849
pii:
doi:

Substances chimiques

Beclin-1 0
Vascular Endothelial Growth Factor A 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : European Research Council
ID : 616891
Pays : International

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Auteurs

Tillmann Bork (T)

Department of Medicine IV, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Wei Liang (W)

Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Oliver Kretz (O)

III Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Simon Lagies (S)

Centre for Integrative Signalling Analysis, University of Freiburg, 79104 Freiburg, Germany.
Institute of Organic Chemistry, University of Freiburg, 79104 Freiburg, Germany.
ORCID: 0000-0002-5245-1781

Kosuke Yamahara (K)

Department of Medicine, Shiga University of Medical Science, Otsu 520-2192, Japan.

Camila Hernando-Erhard (C)

Department of Medicine IV, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Martin Helmstädter (M)

Department of Medicine IV, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
ORCID: 0000-0001-6027-0094

Christoph Schell (C)

Institute of Surgical Pathology, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Bernd Kammerer (B)

Centre for Integrative Signalling Analysis, University of Freiburg, 79104 Freiburg, Germany.
BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany.
ORCID: 0000-0002-4631-8853

Tobias B Huber (TB)

III Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › BECLIN1 Is Essential for Podocyte Secretory...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Bécline-1 › BECLIN1 Is Essential for Podocyte Secretory...
questionsmedicales.fr › Système cardiovasculaire › Barrière de filtration glomérulaire › BECLIN1 Is Essential for Podocyte Secretory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › BECLIN1 Is Essential for Podocyte Secretory...
questionsmedicales.fr › Cellules › Cellules épithéliales › Podocytes › BECLIN1 Is Essential for Podocyte Secretory...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Exocytose › Voie de sécrétion › BECLIN1 Is Essential for Podocyte Secretory...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Facteurs de croissance endothéliale vasculaire › Facteur de croissance endothéliale vasculaire de type A › BECLIN1 Is Essential for Podocyte Secretory...