Phenotypical Conversions of Dermal Adipocytes as Pathophysiological Steps in Inflammatory Cutaneous Disorders.
acne
de-differentiation
dermal adipocytes
psoriasis
re-differentiation
trans-differentiation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Mar 2022
30 Mar 2022
Historique:
received:
07
03
2022
revised:
24
03
2022
accepted:
25
03
2022
entrez:
12
4
2022
pubmed:
13
4
2022
medline:
14
4
2022
Statut:
epublish
Résumé
Adipocytes from the superficial layer of subcutaneous adipose tissue undergo cyclic de- and re-differentiation, which can significantly influence the development of skin inflammation under different cutaneous conditions. This inflammation can be connected with local loading of the reticular dermis with lipids released due to de-differentiation of adipocytes during the catagen phase of the hair follicle cycle. Alternatively, the inflammation parallels a widespread release of cathelicidin, which typically takes place in the anagen phase (especially in the presence of pathogens). Additionally, trans-differentiation of dermal adipocytes into myofibroblasts, which can occur under some pathological conditions, can be responsible for the development of collateral scarring in acne. Here, we provide an overview of such cellular conversions in the skin and discuss their possible involvement in the pathophysiology of inflammatory skin conditions, such as acne and psoriasis.
Identifiants
pubmed: 35409189
pii: ijms23073828
doi: 10.3390/ijms23073828
pmc: PMC8998946
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : R01-DK55758
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01-DK099110
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01-DK131537
Pays : United States
Organisme : NIDDK NIH HHS
ID : RC2-DK118620
Pays : United States
Organisme : NIDDK NIH HHS
ID : P01-AG051459
Pays : United States
Références
Br J Dermatol. 2005 Nov;153(5):937-44
pubmed: 16225603
Diabetes. 2016 Apr;65(4):967-80
pubmed: 26868294
J Biol Chem. 2018 Jan 19;293(3):973-983
pubmed: 29203526
Mol Cell Biol. 2009 Aug;29(16):4467-83
pubmed: 19546236
J Cell Physiol. 2019 Jul;234(7):10270-10280
pubmed: 30561036
J Eur Acad Dermatol Venereol. 2011 Sep;25(9):1054-60
pubmed: 21108671
J Dermatol Sci. 2013 Jun;70(3):159-65
pubmed: 23587732
Cell Metab. 2018 Aug 7;28(2):282-288.e3
pubmed: 29909970
J Immunol. 2012 Sep 15;189(6):3231-41
pubmed: 22904306
J Invest Dermatol. 2010 Feb;130(2):371-7
pubmed: 19710682
Trends Endocrinol Metab. 2016 Jan;27(1):1-10
pubmed: 26643658
Br J Dermatol. 2019 Dec;181(6):1226-1237
pubmed: 30822364
J Cell Sci. 2010 Dec 15;123(Pt 24):4280-91
pubmed: 21098633
J Am Acad Dermatol. 2005 Jan;52(1):23-6
pubmed: 15627076
J Am Acad Dermatol. 2013 Apr;68(4):654-662
pubmed: 23360868
J Invest Dermatol. 2018 Jul;138(7):1518-1528
pubmed: 29454560
Diabetes. 2003 Dec;52(12):2882-7
pubmed: 14633847
Trends Endocrinol Metab. 2011 Jun;22(6):234-40
pubmed: 21419642
J Eur Acad Dermatol Venereol. 2013 Oct;27(10):1293-8
pubmed: 23057623
Curr Genomics. 2018 May;19(4):247-257
pubmed: 29755288
PLoS One. 2014 Aug 25;9(8):e105238
pubmed: 25153527
Science. 2015 Jan 2;347(6217):67-71
pubmed: 25554785
Psoriasis (Auckl). 2017 Feb 03;7:17-25
pubmed: 29387604
J Physiol. 2022 Feb;600(4):847-868
pubmed: 33724479
Science. 2017 Feb 17;355(6326):748-752
pubmed: 28059714
J Invest Dermatol. 2019 May;139(5):1002-1009
pubmed: 30879642
J Invest Dermatol. 2003 Jul;121(1):20-7
pubmed: 12839559
Facial Plast Surg. 2016 Dec;32(6):671-682
pubmed: 28033645
J Cell Physiol. 2018 May;233(5):3784-3793
pubmed: 28926092
Int J Mol Sci. 2019 Dec 20;21(1):
pubmed: 31877626
J Biol Chem. 2004 Jun 11;279(24):25326-32
pubmed: 15084590
J Invest Dermatol. 1998 Apr;110(4):303-10
pubmed: 9540966
Bioessays. 2022 Jan;44(1):e2100207
pubmed: 34766637
Arch Intern Med. 2007 Aug 13-27;167(15):1670-5
pubmed: 17698691
Exp Dermatol. 2014 Sep;23(9):629-31
pubmed: 24841073
Nat Rev Mol Cell Biol. 2019 Mar;20(3):137-155
pubmed: 30523332
Photomed Laser Surg. 2017 Sep;35(9):484-491
pubmed: 28445107
J Invest Dermatol. 1956 Dec;27(6):405-29
pubmed: 13406288
Int J Mol Med. 2012 Nov;30(5):1219-24
pubmed: 22922938
J Clin Invest. 2009 Nov;119(11):3329-39
pubmed: 19855132
Cytokine. 2002 Aug 7;19(3):121-5
pubmed: 12242078
Nature. 2009 Apr 30;458(7242):1131-5
pubmed: 19339967
Arch Dermatol. 2003 May;139(5):668-70
pubmed: 12756111
J Invest Dermatol. 2005 Jan;124(1):22-7
pubmed: 15654949
Nat Commun. 2014 May 23;5:3880
pubmed: 24852213
J Cell Physiol. 2017 Oct;232(10):2887-2899
pubmed: 27987321
Dev Cell. 2015 Mar 23;32(6):678-92
pubmed: 25752962
Nat Rev Mol Cell Biol. 2017 Nov;18(11):671-684
pubmed: 28852221
Yale J Biol Med. 1988 Sep-Oct;61(5):467-76
pubmed: 2462312
NPJ Regen Med. 2019 Apr 26;4:9
pubmed: 31044089
Nat Commun. 2015 Jul 15;6:7687
pubmed: 26173479
J Invest Dermatol. 2018 Sep;138(9):1999-2009
pubmed: 29605673
Exp Dermatol. 2016 Oct;25(10):812-3
pubmed: 26913468
JCI Insight. 2016 Aug 18;1(13):e87146
pubmed: 27668285
Commun Biol. 2019 Oct 4;2:359
pubmed: 31602408
J Am Acad Dermatol. 2019 Sep;81(3):723-729
pubmed: 30978426
Acta Dermatovenerol Croat. 2010;18(3):146-50
pubmed: 20887695
Int J Stem Cells. 2009 May;2(1):76-9
pubmed: 24855523
PLoS One. 2015 Apr 22;10(4):e0125254
pubmed: 25901360
Exp Dermatol. 2019 Apr;28(4):432-435
pubmed: 30776154
NPJ Aging Mech Dis. 2019 Feb 5;5:4
pubmed: 30729030
J Lipid Res. 2014 Dec;55(12):2479-90
pubmed: 25325755
J Invest Dermatol. 2013 Jan;133(1):135-43
pubmed: 22832490
Exp Dermatol. 2021 Jan;30(1):102-111
pubmed: 32866299
Clin Dermatol. 2018 Jan - Feb;36(1):29-40
pubmed: 29241749
Trends Endocrinol Metab. 2019 Feb;30(2):93-105
pubmed: 30558832
J Clin Invest. 2001 Apr;107(8):961-6
pubmed: 11306599
Exp Dermatol. 2015 Nov;24(11):889-91
pubmed: 26121067
Science. 2006 Mar 24;311(5768):1770-3
pubmed: 16497887
Nat Rev Endocrinol. 2018 Mar;14(3):163-173
pubmed: 29327704
J Biol Regul Homeost Agents. 2018 Jan-Feb;32(1):159-161
pubmed: 29504381
J Am Acad Dermatol. 2008 Jan;58(1):56-9
pubmed: 17945383
Immunity. 2019 Jan 15;50(1):121-136.e5
pubmed: 30594464
Eur J Dermatol. 2016 Apr 1;26(2):144-54
pubmed: 27019510
J Clin Invest. 2019 Dec 2;129(12):5327-5342
pubmed: 31503545
Science. 2019 Mar 1;363(6430):989-993
pubmed: 30819964
Exp Dermatol. 2016 Apr;25(4):258-62
pubmed: 26781768
Nat Rev Dis Primers. 2015 Sep 17;1:15029
pubmed: 27189872
Plast Reconstr Surg. 2019 May;143(5):983e-992e
pubmed: 30807494
Cureus. 2018 Oct 24;10(10):e3491
pubmed: 30648033
EMBO J. 2004 Apr 21;23(8):1770-81
pubmed: 15057277
J Invest Dermatol. 2016 Jul;136(7):1460-1470
pubmed: 27021405
Exp Dermatol. 2020 Feb;29(2):177-183
pubmed: 31769542