Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission.
ASD genes
animal model
brain development
glutamate receptors
gut
metabolism
signaling
therapy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Mar 2022
31 Mar 2022
Historique:
received:
28
02
2022
revised:
24
03
2022
accepted:
29
03
2022
entrez:
12
4
2022
pubmed:
13
4
2022
medline:
14
4
2022
Statut:
epublish
Résumé
Disturbances in the glutamatergic system have been increasingly documented in several neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered theories of ASD are based on evidence from patient samples and postmortem studies, as well as from studies documenting abnormalities in glutamatergic gene expression and metabolic pathways, including changes in the gut microbiota glutamate metabolism in patients with ASD. In addition, preclinical studies on animal models have demonstrated glutamatergic neurotransmission deficits and altered expression of glutamate synaptic proteins. At present, there are no approved glutamatergic drugs for ASD, but several ongoing clinical trials are currently focusing on evaluating in autistic patients glutamatergic pharmaceuticals already approved for other conditions. In this review, we provide an overview of the literature concerning the role of glutamatergic neurotransmission in the pathophysiology of ASD and as a potential target for novel treatments.
Identifiants
pubmed: 35409220
pii: ijms23073861
doi: 10.3390/ijms23073861
pmc: PMC8998955
pii:
doi:
Substances chimiques
Glutamic Acid
3KX376GY7L
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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