Genotoxic Effects of Lead and Their Impact on the Expression of DNA Repair Genes.
DNA repair
gene expression
genotoxicity
lead
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
03 04 2022
03 04 2022
Historique:
received:
28
02
2022
revised:
23
03
2022
accepted:
02
04
2022
entrez:
12
4
2022
pubmed:
13
4
2022
medline:
14
4
2022
Statut:
epublish
Résumé
Exposure to lead (Pb) continues to be a significant worldwide problem. Pb is a highly poisonous heavy metal affecting several organ systems in the body. Although Pb has been shown to be genotoxic to experimental animals and humans, the underlying mechanisms are still not understood. An indirect mechanism related to the inhibition of DNA repair systems by Pb has been suggested. Heavy metals can interfere with the activities of several proteins and gene expressions. Recent studies gathered in this review article demonstrated an altered expression of DNA repair genes due to Pb toxicity. However, their findings are conflicting. Furthermore, the interaction of Pb and epigenetic mechanisms regulating gene expression may have a crucial role in the inhibition of DNA repair systems. Therefore, additional studies are needed to evaluate these findings and to obtain a complete picture of the genotoxic properties of Pb and the underlying mechanisms that may have a crucial role in carcinogenesis.
Identifiants
pubmed: 35409986
pii: ijerph19074307
doi: 10.3390/ijerph19074307
pmc: PMC8998702
pii:
doi:
Substances chimiques
Metals, Heavy
0
Lead
2P299V784P
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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