The Association between Assisted Reproductive Technology and the Risk of Autism Spectrum Disorders among Offspring: A Meta-analysis.
Assisted reproductive technology
autism spectrum disorders
heterogeneity
infertility.
meta-analysis
psychiatric disorders
Journal
Current pediatric reviews
ISSN: 1875-6336
Titre abrégé: Curr Pediatr Rev
Pays: United Arab Emirates
ID NLM: 101240290
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
09
2021
revised:
21
01
2022
accepted:
02
02
2022
pubmed:
13
4
2022
medline:
28
1
2023
entrez:
12
4
2022
Statut:
ppublish
Résumé
This review aimed to determine the association between assisted reproductive technology (ART) and increased chances of having an autistic child. The Web of Science, PubMed, and Scopus databases were systematically searched for studies published until December 2020 with the restricted English language. The Newcastle-Ottawa Scale (NOS) for cohort and case-control studies has been used for the evaluation of quality in individual studies. We evaluated the heterogeneity among the studies using I-squared. Publication bias was assessed using the funnel plot and Egger's and Begg's tests. We presented results using odds ratio (OR) and relative ratio (RR) estimates with its 95% confidence intervals (CI) using a randomeffects model. In total, 18 articles were included in the present study. The overall findings of the present meta-analysis show that the use of ART didn't associate with the risk of autism spectrum disorders (ASD) among offspring based on OR and RR (OR = 1.04, 95% CI: 0.88-1.21) and (RR = 1 .26, 95% CI: 0.96- 1 .55), respectively. We showed a significant association between ART and the risk of ASD in Asia than in the other regions without heterogeneity. Our result showed that the risk of ASD was not increased in children born from ART. Possible interaction between ART and other regions with increased risk of ASD is important to point and future studies of this topic were recommended.
Sections du résumé
BACKGROUND
BACKGROUND
This review aimed to determine the association between assisted reproductive technology (ART) and increased chances of having an autistic child.
METHODS
METHODS
The Web of Science, PubMed, and Scopus databases were systematically searched for studies published until December 2020 with the restricted English language. The Newcastle-Ottawa Scale (NOS) for cohort and case-control studies has been used for the evaluation of quality in individual studies. We evaluated the heterogeneity among the studies using I-squared. Publication bias was assessed using the funnel plot and Egger's and Begg's tests. We presented results using odds ratio (OR) and relative ratio (RR) estimates with its 95% confidence intervals (CI) using a randomeffects model.
RESULTS
RESULTS
In total, 18 articles were included in the present study. The overall findings of the present meta-analysis show that the use of ART didn't associate with the risk of autism spectrum disorders (ASD) among offspring based on OR and RR (OR = 1.04, 95% CI: 0.88-1.21) and (RR = 1 .26, 95% CI: 0.96- 1 .55), respectively. We showed a significant association between ART and the risk of ASD in Asia than in the other regions without heterogeneity.
CONCLUSION
CONCLUSIONS
Our result showed that the risk of ASD was not increased in children born from ART. Possible interaction between ART and other regions with increased risk of ASD is important to point and future studies of this topic were recommended.
Identifiants
pubmed: 35410610
pii: CPR-EPUB-122433
doi: 10.2174/1573396318666220410231435
doi:
Types de publication
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Pagination
83-89Subventions
Organisme : Hamadan University of Medical Sciences
ID : 9910307636
Informations de copyright
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