Mutational Analysis of

BRCA1/2 Ki-67 NGS hereditary breast cancer tumor grading

Journal

Cancer management and research
ISSN: 1179-1322
Titre abrégé: Cancer Manag Res
Pays: New Zealand
ID NLM: 101512700

Informations de publication

Date de publication:
2022
Historique:
received: 19 11 2021
accepted: 26 01 2022
entrez: 12 4 2022
pubmed: 13 4 2022
medline: 13 4 2022
Statut: epublish

Résumé

Germline mutations of Mutational status was assessed in a cohort of 389 BC patients, using next generation sequencing. The presence of alterations was correlated with tumor grading and proliferation index. Overall, 35 patients (9%) harbored a Our findings provide an overview about

Identifiants

pubmed: 35411189
doi: 10.2147/CMAR.S348529
pii: 348529
pmc: PMC8994564
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1341-1352

Informations de copyright

© 2022 Stella et al.

Déclaration de conflit d'intérêts

Federica Martorana reports honoraria from Istituto Gentili, Lilly, Novartis, Pfizer. The other authors declare no conflicts of interest in this work.

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Auteurs

Stefania Stella (S)

Department of Clinical and Experimental Medicine, University of Catania, Catania, 95123, Italy.
Center of Experimental Oncology and Hematology, A.O.U. Policlinico "G. Rodolico - San Marco", Catania, 95123, Italy.

Silvia Rita Vitale (SR)

Department of Clinical and Experimental Medicine, University of Catania, Catania, 95123, Italy.
Center of Experimental Oncology and Hematology, A.O.U. Policlinico "G. Rodolico - San Marco", Catania, 95123, Italy.

Federica Martorana (F)

Department of Clinical and Experimental Medicine, University of Catania, Catania, 95123, Italy.
Center of Experimental Oncology and Hematology, A.O.U. Policlinico "G. Rodolico - San Marco", Catania, 95123, Italy.

Michele Massimino (M)

Department of Clinical and Experimental Medicine, University of Catania, Catania, 95123, Italy.
Center of Experimental Oncology and Hematology, A.O.U. Policlinico "G. Rodolico - San Marco", Catania, 95123, Italy.

Giuliana Pavone (G)

Medical Oncology, A.O.U. Policlinico "G. Rodolico - San Marco", Catania, 95123, Italy.

Katia Lanzafame (K)

Medical Oncology, A.O.U. Policlinico "G. Rodolico - San Marco", Catania, 95123, Italy.

Sebastiano Bianca (S)

Medical Genetics, ARNAS Garibaldi, Catania, 95123, Italy.

Chiara Barone (C)

Medical Genetics, ASP, Siracusa, 96100, Italy.

Cristina Gorgone (C)

Department of Biomedical and Biotechnological Sciences, Medical Genetics, University of Catania, Catania, 95123, Italy.

Marco Fichera (M)

Department of Biomedical and Biotechnological Sciences, Medical Genetics, University of Catania, Catania, 95123, Italy.
Oasi Research Institute-IRCCS, Troina, 94018, Italy.

Livia Manzella (L)

Department of Clinical and Experimental Medicine, University of Catania, Catania, 95123, Italy.
Center of Experimental Oncology and Hematology, A.O.U. Policlinico "G. Rodolico - San Marco", Catania, 95123, Italy.

Classifications MeSH