Molecular Evidence of Coinfection with Acute Respiratory Viruses and High Prevalence of SARS-CoV-2 among Patients Presenting Flu-Like Illness in Bukavu City, Democratic Republic of Congo.
Journal
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
ISSN: 1712-9532
Titre abrégé: Can J Infect Dis Med Microbiol
Pays: Egypt
ID NLM: 101226876
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
10
2021
accepted:
23
03
2022
entrez:
12
4
2022
pubmed:
13
4
2022
medline:
13
4
2022
Statut:
epublish
Résumé
The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with clinical manifestation cases that are almost similar to those of common respiratory viral infections. This study determined the prevalence of SARS-CoV-2 and other acute respiratory viruses among patients with flu-like symptoms in Bukavu city, Democratic Republic of Congo. We screened 1352 individuals with flu-like illnesses seeking treatment in 10 health facilities. Nasopharyngeal swab specimens were collected to detect SARS-CoV-2 using real-time reverse transcription-polymerase chain reaction (RT-PCR), and 10 common respiratory viruses were detected by multiplex reverse transcription-polymerase chain reaction assay. Overall, 13.9% (188/1352) of patients were confirmed positive for SARS-CoV-2. Influenza A 5.6% (56/1352) and Influenza B 0.9% (12/1352) were the most common respiratory viruses detected. Overall, more than two cases of the other acute respiratory viruses were detected. Frequently observed symptoms associated with SARS-CoV-2 positivity were shivering (47.8%; OR = 1.8; CI: 0.88-1.35), cough (89.6%; OR = 6.5, CI: 2.16-28.2), and myalgia and dizziness (59.7%; OR = 2.7; CI: 1.36-5.85). Moreover, coinfection was observed in 12 (11.5%) specimens. SARS-CoV-2 and influenza A were the most cooccurring infections, accounting for 33.3% of all positive cases. This study demonstrates cases of COVID-19 infections cooccurring with other acute respiratory infections in Bukavu city during the ongoing outbreak of COVID-19. Therefore, testing for respiratory viruses should be performed in all patients with flu-like symptoms for effective surveillance of the transmission patterns in the COVID-19 affected areas for optimal treatment and effective disease management.
Identifiants
pubmed: 35411212
doi: 10.1155/2022/1553266
pmc: PMC8994514
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1553266Informations de copyright
Copyright © 2022 Patrick Bisimwa Ntagereka et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
R I Med J (2013). 2020 Mar 19;103(2):75-76
pubmed: 32192233
J Med Virol. 2020 Apr;92(4):401-402
pubmed: 31950516
Chest. 2016 Feb;149(2):526-534
pubmed: 26203671
J Med Virol. 2018 May;90(5):828-835
pubmed: 29388679
Laryngoscope. 2020 Jul;130(7):1787
pubmed: 32237238
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Int J Infect Dis. 2021 Apr;105:763-768
pubmed: 33711523
JAMA. 2020 May 19;323(19):1969-1971
pubmed: 32275293
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Microbes Infect. 2020 Oct;22(9):481-488
pubmed: 32561409
Zhonghua Liu Xing Bing Xue Za Zhi. 2019 Aug 10;40(8):904-910
pubmed: 31484252
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Pan Afr Med J. 2021 Jan 27;38:93
pubmed: 33889259
Int J Infect Dis. 2020 Oct;99:266-268
pubmed: 32771632
Arch Intern Med. 2000 Nov 27;160(21):3243-7
pubmed: 11088084
J Med Virol. 2020 Nov;92(11):2870-2873
pubmed: 32530499
Euro Surveill. 2020 Jan;25(3):
pubmed: 31992387
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
Am J Trop Med Hyg. 2021 Feb 16;104(4):1526-1530
pubmed: 33591936
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Emerg Infect Dis. 2020 Jun;26(6):1324-1326
pubmed: 32160148
PLoS One. 2017 Aug 16;12(8):e0182191
pubmed: 28813449
Nat Med. 2020 May;26(5):676-680
pubmed: 32371934
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
J Med Virol. 2016 Nov;88(11):1874-81
pubmed: 27061822
PLoS One. 2016 Dec 9;11(12):e0167866
pubmed: 27936139
Clin Microbiol Infect. 2009 Dec;15(12):1146-53
pubmed: 19456830
JAMA Neurol. 2020 Jun 1;77(6):683-690
pubmed: 32275288
Int J Infect Dis. 2021 Apr;105:617-620
pubmed: 33640570