Efficacy and safety of a thermal fractional skin rejuvenation system (Tixel) for the treatment of facial and/or scalp actinic keratoses.
Actinic keratosis
Solar keratosis
Tixel
Journal
Lasers in medical science
ISSN: 1435-604X
Titre abrégé: Lasers Med Sci
Pays: England
ID NLM: 8611515
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
18
10
2021
accepted:
01
04
2022
pubmed:
13
4
2022
medline:
15
9
2022
entrez:
12
4
2022
Statut:
ppublish
Résumé
Actinic keratoses are common cutaneous lesions with a potential to progress to invasive squamous cell carcinoma. Therefore, treatment is crucial. The Tixel® is a noninvasive thermomechanical device designed to transfer heat to the upper dermis in a controlled manner according to a predetermined setting. This study aimed to evaluate the safety and efficacy of a thermomechanical fractional skin resurfacing technology for the treatment of facial and scalp actinic keratoses. A prospective, open-label, before-after study was conducted in a tertiary medical centre from May 2020 to April 2021. Patients presenting with facial/scalp actinic keratoses of mild-to-moderate thickness underwent 2 or 3 Tixel treatments (depending on clinical improvement), 3-4 weeks apart. The reduction in lesion count and overall improvement in appearance were assessed by clinical examination and digital photography. Findings were compared between baseline and follow-up at 3 months after the last treatment session. Patient satisfaction was evaluated by questionnaire, and adverse effects were documented. A total of 20 patients participated in the study. All completed 2-3 treatments and follow-up visits. Assessment of digital photographs was performed by 2 assessors blinded to the timepoint at which each photo was taken (before or after treatment). The average number of lesions at baseline was 9.8 (± 4.8) and the mean reduction in lesion count was 7.9 (± 4.4) (80.6%). Complete clearance was observed in 31.6% of patients. No adverse effects were noted during treatment and follow-up. Most patients reported being "very satisfied" or "satisfied" with the treatment results (85%) and experience (95%). Treating facial and scalp actinic keratoses with the Tixel device was found to be effective and safe.
Identifiants
pubmed: 35412157
doi: 10.1007/s10103-022-03558-4
pii: 10.1007/s10103-022-03558-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2899-2905Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.
Références
Warino L, Tusa M, Camacho F, Teuschler H, Fleischer AB Jr, Feldman SR (2006) Frequency and cost of actinic keratosis treatment. Dermatol Surg 32(8):1045–1049
pubmed: 16918567
Flohil SC, van der Leest RJ, Dowlatshahi EA, Hofman A, de Vries E, Nijsten T (2013) Prevalence of actinic keratosis and its risk factors in the general population: the Rotterdam Study. J Investig Dermatol 133(8):1971–1978
doi: 10.1038/jid.2013.134
Marks R, Rennie G, Selwood TS (1988) Malignant transformation of solar keratoses to squamous cell carcinoma. Lancet Lond Engl 1(8589):795–797
doi: 10.1016/S0140-6736(88)91658-3
Glogau RG (2000) The risk of progression to invasive disease. J Am Acad Dermatol 42(1 Pt 2):23–24
doi: 10.1067/mjd.2000.103339
Dianzani C, Conforti C, Giuffrida R, Corneli P, di Meo N, Farinazzo E et al (2020) Current therapies for actinic keratosis. Int J Dermatol 59(6):677–684
doi: 10.1111/ijd.14767
Cramer P, Stockfleth E (2020) Actinic keratosis: where do we stand and where is the future going to take us? Expert Opin Emerg Drugs 25(1):49–58
doi: 10.1080/14728214.2020.1730810
Werner RN, Stockfleth E, Connolly SM, Correia O, Erdmann R, Foley P, International League of Dermatological Societies, European Dermatology Forum et al (2015) Evidence- and consensus-based (S3) Guidelines for the Treatment of Actinic Keratosis - International League of Dermatological Societies in cooperation with the European Dermatology Forum - Short version. J Eur Acad Dermatol Venereol 29(11):2069–79
doi: 10.1111/jdv.13180
Ianhez M, Miot HA, Bagatin E (2014) Liquid nitrogen for the treatment of actinic keratosis: a longitudinal assessment. Cryobiology 69(1):140–143
doi: 10.1016/j.cryobiol.2014.06.006
Marmur ES, Schmults CD, Goldberg DJ (2004) A review of laser and photodynamic therapy for the treatment of nonmelanoma skin cancer. Dermatologic Surg 30(2 Pt 2):264–271
Chetty P, Choi F, Mitchell T (2015) Primary care review of actinic keratosis and its therapeutic options: a global perspective. Dermatol Ther (Heidelb) 5(1):19–35
doi: 10.1007/s13555-015-0070-9
Krawtchenko N, Roewert-Huber J, Ulrich M, Mann I, Sterry W, Stockfleth E (2007) A randomised study of topical 5% imiquimod vs. topical 5-fluorouracil vs. cryosurgery in immunocompetent patients with actinic keratoses:a comparison of clinical and histological outcomes including 1-year follow-up. Br J Dermatol 157(Suppl 2):34–40
doi: 10.1111/j.1365-2133.2007.08271.x
Rivers JK, Arlette J, Shear N, Guenther L, Carey W, Poulin Y (2002) Topical treatment of actinic keratoses with 3.0% diclofenac in 2.5% hyaluronan gel. Br J Dermatol 146(1):94–100
doi: 10.1046/j.1365-2133.2002.04561.x
Berman B, Amini S (2012) Pharmacotherapy of actinic keratosis: an update. Expert Opin Pharmacother 13(13):1847–1871
doi: 10.1517/14656566.2012.716039
Dirschka T, Peris K, Gupta G, Alomar A, Aractingi S, Dakovic R et al (2016) Imiquimod 3.75% in actinic keratosis: efficacy in patients with and without rest periods during treatment. J Eur Acad Dermatol Venereol. 30(8):1416–7
doi: 10.1111/jdv.13260
Stockfleth E, Gupta G, Peris K, Aractingi S, Dakovic R, Alomar A (2014) Reduction in lesions from Lmax: a new concept for assessing efficacy of field-directed therapy for actinic keratosis. Results with imiquimod 3.75%. Eur J Dermatol. 24(1):23–7
doi: 10.1684/ejd.2014.2265
Lacour JP, Ulrich C, Gilaberte Y, Von Felbert V, Basset-Seguin N, Dreno B et al (2015) Daylight photodynamic therapy with methyl aminolevulinate cream is effective and nearly painless in treating actinic keratoses: a randomised, investigator-blinded, controlled, phase III study throughout Europe. J Eur Acad Dermatol Venereol 29:2342–2348
doi: 10.1111/jdv.13228
Enk CD, Levi A (2012) Low-irradiance red LED traffic lamps as light source in PDT for actinic keratoses. Photodermatol Photoimmunol Photomed 28(6):332–334
doi: 10.1111/j.1600-0781.2012.00694.x
Damian DL (2017) Nicotinamide for skin cancer chemoprevention. Australas J Dermatol 58(3):174–180
doi: 10.1111/ajd.12631
Sharon E, Snast I, Lapidoth M, Kaftory R, Mimouni D, Hodak E et al (2021) Laser Treatment for non-melanoma skin cancer: a systematic review and meta-analysis. Am J Clin Dermatol 22(1):25–38
doi: 10.1007/s40257-020-00562-8
Trimas SJ, Ellis DA, Metz RD (1997) The carbon dioxide laser. An alternative for the treatment of actinically damaged skin. Dermatol Surg 23(10):885–9
doi: 10.1111/j.1524-4725.1997.tb00741.x
Fulton JE, Rahimi AD, Helton P, Dahlberg K, Kelly AG (1999) Disappointing results following resurfacing of facial skin with CO2 lasers for prophylaxis of keratoses and cancers. Dermatol Surg 25(9):729–732
doi: 10.1046/j.1524-4725.1999.99035.x
Elman M, Fournier N, Barnéon G, Bernstein EF, Lask G (2016) Fractional treatment of aging skin with Tixel, a clinical and histological evaluation. J Cosmet Laser Ther 18(1):31–37
pubmed: 26073117
Daniely D, Judodihardjo H, Rajpar SF, Mehrabi JN, Artzi O (2021) Thermo-mechanical fractional injury therapy for facial skin rejuvenation in skin types II to V: a retrospective double-center chart review. Lasers Surg Med. https://doi.org/10.1002/lsm.23400
doi: 10.1002/lsm.23400
pubmed: 34787919
Kokolakis G, Von Grawert L, Ulrich M, Lademann J, Zuberbier T, Hofmann MA (2020) Wound healing process after thermomechanical skin ablation. Lasers Surg Med 52(8):730–734
doi: 10.1002/lsm.23213
Shavit R, Dierickx C (2020) A new method for percutaneous drug delivery by thermo-mechanical fractional injury. Lasers Surg Med 52(1):61–69
doi: 10.1002/lsm.23125
Hilerowicz Y, Friedman O, Zur E, Ziv R, Koren A, Salameh F et al (2020) Thermomechanical ablation-assisted photodynamic therapy for the treatment of acne vulgaris. A retrospective chart review of 30 patients. Lasers Surg Med. 52:966–70
doi: 10.1002/lsm.23246
Artzi O, Koren A, Niv R, Mehrabi JN, Mashiah J, Friedman O (2020) A new approach in the treatment of pediatric hypertrophic burn scars: Tixel-associated topical triamcinolone acetonide and 5-fluorouracil delivery. J Cosmet Dermatol 19(1):131–134
doi: 10.1111/jocd.13192
Friedman O, Koren A, Niv R, Mehrabi JN, Artzi O (2019) The toxic edge - a novel treatment for refractory erythema and flushing of rosacea. Lasers Surg Med 51(4):325–331
doi: 10.1002/lsm.23023