Optimization of the BCLC Staging System for Locoregional Therapy for Hepatocellular Carcinoma by Using Quantitative Tumor Burden Imaging Biomarkers at MRI.

Biomarkers, Tumor Carcinoma, Hepatocellular / diagnostic imaging Chemoembolization, Therapeutic Humans Liver Neoplasms / diagnostic imaging Magnetic Resonance Imaging Male Middle Aged Neoplasm Staging Retrospective Studies Treatment Outcome Tumor Burden

Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
07 2022
Historique:
pubmed: 13 4 2022
medline: 24 6 2022
entrez: 12 4 2022
Statut: ppublish

Résumé

Background Patients with intermediate- and advanced-stage hepatocellular carcinoma (HCC) represent a highly heterogeneous patient collective with substantial differences in overall survival. Purpose To evaluate enhancing tumor volume (ETV) and enhancing tumor burden (ETB) as new criteria within the Barcelona Clinic Liver Cancer (BCLC) staging system for optimized allocation of patients with intermediate- and advanced-stage HCC to undergo transarterial chemoembolization (TACE). Materials and Methods In this retrospective study, 682 patients with HCC who underwent conventional TACE or TACE with drug-eluting beads from January 2000 to December 2014 were evaluated. Quantitative three-dimensional analysis of contrast-enhanced MRI was performed to determine thresholds of ETV and ETB (ratio of ETV to normal liver volume). Patients with ETV below 65 cm

Identifiants

DOI: 10.1148/radiol.212426 PMID: 35412368 PMC: PMC9270683
pubmed: 35412368
doi: 10.1148/radiol.212426
pmc: PMC9270683
mid: NIHMS1822562
doi:

Substances chimiques

Biomarkers, Tumor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

228-237

Subventions

Organisme : BLRD VA
ID : IK6 BX004601
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034989
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA206180
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States

Commentaires et corrections

Type : CommentIn

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Auteurs

Tabea Borde (T)

From the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0003-3019-5470

Nariman Nezami (N)

From the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0002-8829-1548

Fabian Laage Gaupp (F)

From the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0001-6940-9793

Lynn Jeanette Savic (LJ)

From the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0003-2115-6728

Tamar Taddei (T)

From the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0002-6500-1739

Ariel Jaffe (A)

From the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).

Mario Strazzabosco (M)

From the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0002-1995-6331

MingDe Lin (M)

From the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0001-7641-2595

Rafael Duran (R)

From the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0003-2610-9517

Christos Georgiades (C)

From the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).

Kelvin Hong (K)

From the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0002-8420-5307

Julius Chapiro (J)

From the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0002-1984-2246

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Optimization of the BCLC Staging System for...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Carcinome hépatocellulaire › Optimization of the BCLC Staging System for...
questionsmedicales.fr › Thérapeutique › Occlusion thérapeutique › Embolisation thérapeutique › Chimioembolisation thérapeutique › Optimization of the BCLC Staging System for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Optimization of the BCLC Staging System for...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Optimization of the BCLC Staging System for...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Optimization of the BCLC Staging System for...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Optimization of the BCLC Staging System for...
questionsmedicales.fr › Diagnostic › Pronostic › Stadification tumorale › Optimization of the BCLC Staging System for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Optimization of the BCLC Staging System for...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Optimization of the BCLC Staging System for...
questionsmedicales.fr › Techniques d'investigation › Charge tumorale › Optimization of the BCLC Staging System for...