Chemical biology and medicinal chemistry of RNA methyltransferases.
Journal
Nucleic acids research
ISSN: 1362-4962
Titre abrégé: Nucleic Acids Res
Pays: England
ID NLM: 0411011
Informations de publication
Date de publication:
06 05 2022
06 05 2022
Historique:
accepted:
08
04
2022
revised:
17
03
2022
received:
24
11
2021
pubmed:
13
4
2022
medline:
10
5
2022
entrez:
12
4
2022
Statut:
ppublish
Résumé
RNA methyltransferases (MTases) are ubiquitous enzymes whose hitherto low profile in medicinal chemistry, contrasts with the surging interest in RNA methylation, the arguably most important aspect of the new field of epitranscriptomics. As MTases become validated as drug targets in all major fields of biomedicine, the development of small molecule compounds as tools and inhibitors is picking up considerable momentum, in academia as well as in biotech. Here we discuss the development of small molecules for two related aspects of chemical biology. Firstly, derivates of the ubiquitous cofactor S-adenosyl-l-methionine (SAM) are being developed as bioconjugation tools for targeted transfer of functional groups and labels to increasingly visible targets. Secondly, SAM-derived compounds are being investigated for their ability to act as inhibitors of RNA MTases. Drug development is moving from derivatives of cosubstrates towards higher generation compounds that may address allosteric sites in addition to the catalytic centre. Progress in assay development and screening techniques from medicinal chemistry have led to recent breakthroughs, e.g. in addressing human enzymes targeted for their role in cancer. Spurred by the current pandemic, new inhibitors against coronaviral MTases have emerged at a spectacular rate, including a repurposed drug which is now in clinical trial.
Identifiants
pubmed: 35412633
pii: 6567480
doi: 10.1093/nar/gkac224
pmc: PMC9071492
doi:
Substances chimiques
RNA
63231-63-0
S-Adenosylmethionine
7LP2MPO46S
Methyltransferases
EC 2.1.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4216-4245Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.
Références
Front Cell Infect Microbiol. 2021 Apr 07;11:665379
pubmed: 33898335
PLoS One. 2013 Oct 09;8(10):e76900
pubmed: 24130807
Anal Biochem. 2010 Jun 15;401(2):203-10
pubmed: 20227379
Antimicrob Agents Chemother. 2020 Jun 23;64(7):
pubmed: 32340991
J Med Chem. 2010 Feb 25;53(4):1483-95
pubmed: 20108931
Chemometr Intell Lab Syst. 2021 Oct 15;217:104421
pubmed: 34538993
Epigenomics. 2016 Mar;8(3):321-39
pubmed: 26950288
Chemistry. 2020 Sep 1;26(49):11266-11275
pubmed: 32259329
J Biomol Screen. 2016 Jun;21(5):490-5
pubmed: 26582803
J Virol. 2017 Feb 14;91(5):
pubmed: 28031370
Nucleic Acids Res. 2014 Apr;42(7):e50
pubmed: 24452797
Angew Chem Int Ed Engl. 2010 Feb 22;49(9):1540-73
pubmed: 20166107
J Fluoresc. 2013 May;23(3):381-6
pubmed: 23408091
J Am Chem Soc. 2003 Mar 26;125(12):3486-92
pubmed: 12643710
BMC Bioinformatics. 2011;12 Suppl 13:S24
pubmed: 22373153
J Am Chem Soc. 2007 Mar 14;129(10):2758-9
pubmed: 17309265
Structure. 2002 Oct;10(10):1303-15
pubmed: 12377117
J Pharm Biomed Anal. 2002 Jul 31;29(5):963-8
pubmed: 12093531
J Antibiot (Tokyo). 1991 Oct;44(10):1141-7
pubmed: 1720117
Wiley Interdiscip Rev RNA. 2018 Jan;9(1):
pubmed: 28853213
Nat Rev Drug Discov. 2018 Jun;17(6):435-453
pubmed: 29773918
PLoS Genet. 2014 Apr 17;10(4):e1004296
pubmed: 24743450
Cell. 1975 Oct;6(2):185-95
pubmed: 1182800
Nat Rev Drug Discov. 2018 May;17(5):353-377
pubmed: 29545548
Front Microbiol. 2017 Dec 05;8:2374
pubmed: 29259584
Assay Drug Dev Technol. 2015 May;13(4):235-40
pubmed: 26065559
J Virol. 2008 May;82(9):4295-307
pubmed: 18305027
ChemMedChem. 2008 Feb;3(2):316-22
pubmed: 18038381
Nat Rev Drug Discov. 2019 Nov;18(12):892-894
pubmed: 31780844
J Bacteriol. 1987 Aug;169(8):3857-60
pubmed: 2440853
Chembiochem. 2007 Sep 3;8(13):1516-9
pubmed: 17654629
J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Apr 15;1113:91-97
pubmed: 30901734
Methods Mol Biol. 2016;1428:45-60
pubmed: 27236791
J Med Chem. 1976 Oct;19(10):1191-5
pubmed: 994148
Nat Rev Genet. 2012 Apr 03;13(5):343-57
pubmed: 22473383
Nat Rev Mol Cell Biol. 2014 May;15(5):313-26
pubmed: 24713629
Nat Struct Biol. 1998 Jul;5(7):585-92
pubmed: 9665173
Nat Biotechnol. 2018 Dec 6;36(12):1123-1124
pubmed: 30520856
J Med Chem. 1976 May;19(5):684-91
pubmed: 1271409
Nat Biotechnol. 2013 May;31(5):458-64
pubmed: 23604283
Comput Struct Biotechnol J. 2020;18:2757-2765
pubmed: 33020707
Drug Target Insights. 2017 Apr 20;11:1177392817701726
pubmed: 28469408
Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13280-13286
pubmed: 33751748
Nat Struct Biol. 2002 Nov;9(11):833-8
pubmed: 12389038
SLAS Discov. 2020 Apr;25(4):361-371
pubmed: 31585521
J Tradit Complement Med. 2022 Jan;12(1):35-43
pubmed: 34099976
J Antibiot (Tokyo). 1973 Aug;26(8):463-5
pubmed: 4792069
Chembiochem. 2006 Feb;7(2):243-5
pubmed: 16365907
J Biol Chem. 2014 Sep 12;289(37):25783-96
pubmed: 25074927
Antiviral Res. 2008 Oct;80(1):1-10
pubmed: 18571739
Bioorg Med Chem. 2020 Nov 15;28(22):115713
pubmed: 33128910
Anal Biochem. 2012 Apr 1;423(1):171-7
pubmed: 22342622
Eur J Med Chem. 2020 Sep 1;201:112557
pubmed: 32563813
Rapid Commun Mass Spectrom. 2002;16(1):43-52
pubmed: 11754246
Annu Rev Biochem. 1995;64:721-62
pubmed: 7574499
J Biol Chem. 1978 Jun 25;253(12):4075-7
pubmed: 659406
BMC Res Notes. 2014 Jul 10;7:440
pubmed: 25012753
Viruses. 2020 May 10;12(5):
pubmed: 32397643
Life (Basel). 2021 Jun 25;11(7):
pubmed: 34202239
mSystems. 2019 Oct 15;4(5):
pubmed: 31615876
Structure. 2000 Aug 15;8(8):817-30
pubmed: 10997901
Biomed Res Int. 2020 Oct 13;2020:6237160
pubmed: 33102585
Antiviral Res. 2009 Jul;83(1):71-9
pubmed: 19501258
Antimicrob Agents Chemother. 2002 Jun;46(6):1629-33
pubmed: 12019067
Expert Rev Anticancer Ther. 2018 Dec;18(12):1249-1270
pubmed: 30259761
Genes Dev. 2021 Jul 1;35(13-14):1005-1019
pubmed: 34168039
Antiviral Res. 2013 Mar;97(3):232-9
pubmed: 23267828
Mol Cell. 2021 Aug 19;81(16):3323-3338.e14
pubmed: 34352207
J Chromatogr B Biomed Sci Appl. 1997 Aug 15;696(1):145-52
pubmed: 9300919
Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1917-20
pubmed: 26694947
RNA Biol. 2019 Jun;16(6):798-808
pubmed: 30879411
Eur J Med Chem. 2018 Feb 25;146:60-67
pubmed: 29396363
J Med Chem. 2002 Jun 6;45(12):2615-23
pubmed: 12036371
J Mass Spectrom. 2012 Aug;47(8):1074-82
pubmed: 22899517
Biochemistry. 2016 Mar 22;55(11):1557-69
pubmed: 26652298
J Biol Chem. 2008 Jul 11;283(28):19410-21
pubmed: 18469001
Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748):
pubmed: 29685962
Mol Cell. 2019 May 16;74(4):640-650
pubmed: 31100245
Nat Rev Microbiol. 2020 Oct;18(10):559-570
pubmed: 32533130
Bioinformation. 2014 Jan 29;10(1):23-7
pubmed: 24516322
Antiviral Res. 2017 Aug;144:330-339
pubmed: 28676301
J Med Chem. 2022 Jan 27;65(2):922-934
pubmed: 33476146
Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8446-76
pubmed: 22829531
Curr Opin Cell Biol. 2014 Dec;31:1-7
pubmed: 25014650
J Med Chem. 2006 Apr 6;49(7):2353-6
pubmed: 16570931
Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0256620
pubmed: 33875421
SLAS Discov. 2021 Oct;26(9):1200-1211
pubmed: 34192965
Nucleic Acids Res. 2012 Aug;40(14):6765-73
pubmed: 22564896
Nature. 2021 May;593(7860):597-601
pubmed: 33902106
Methods Appl Fluoresc. 2017 Mar 09;5(1):012002
pubmed: 28276338
Anal Chem. 2011 Jun 15;83(12):4996-5004
pubmed: 21545095
J Biol Chem. 1979 Sep 25;254(18):9094-100
pubmed: 383712
Org Biomol Chem. 2013 Nov 21;11(43):7606-10
pubmed: 24100405
Proteome Sci. 2017 Jun 24;15:14
pubmed: 28652856
Biochem Pharmacol. 2017 Apr 1;129:1-13
pubmed: 27956110
Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10899-903
pubmed: 27511141
Nucleic Acids Res. 2005 Mar 18;33(5):1644-52
pubmed: 15778434
Open Biol. 2019 Apr 26;9(4):190052
pubmed: 30991934
Nucleic Acids Res. 2022 Jan 25;50(2):635-650
pubmed: 35018474
ChemMedChem. 2020 Feb 17;15(4):385-390
pubmed: 31805205
Nat Commun. 2020 Jul 24;11(1):3717
pubmed: 32709887
Nucleic Acids Res. 2011 Mar;39(5):1943-52
pubmed: 21037259
Genome Biol. 2005;6(8):227
pubmed: 16086857
Chem Soc Rev. 2015 Aug 7;44(15):5495-551
pubmed: 26000775
Int J Biochem. 1992 Dec;24(12):1917-24
pubmed: 1473604
Anal Biochem. 2006 Mar 15;350(2):249-55
pubmed: 16460659
Biomark Res. 2020 Sep 14;8:43
pubmed: 32944246
Science. 2021 Sep 03;373(6559):1142-1146
pubmed: 34315827
Biochemistry. 2004 Oct 26;43(42):13510-24
pubmed: 15491158
Antimicrob Agents Chemother. 2013 Aug;57(8):3843-56
pubmed: 23733469
Nat Cell Biol. 2018 May;20(5):535-540
pubmed: 29695786
Front Biol (Beijing). 2010 Aug 1;5(4):286-303
pubmed: 21927615
J Am Chem Soc. 2008 Apr 9;130(14):4574-5
pubmed: 18338885
Virology. 2010 Sep 30;405(2):568-78
pubmed: 20655081
J Pharm Sci. 1986 Feb;75(2):142-5
pubmed: 3958922
J Biomol Struct Dyn. 2021 Nov;39(18):7306-7321
pubmed: 32835632
J Am Chem Soc. 2017 Dec 6;139(48):17213-17216
pubmed: 29116772
J Chem Inf Model. 2020 Feb 24;60(2):562-568
pubmed: 31985225
Antiviral Res. 2021 Sep;193:105142
pubmed: 34303749
Nat Commun. 2013;4:2190
pubmed: 23877302
Chem Sci. 2015 Feb 1;6(2):1362-1369
pubmed: 29560223
J Med Chem. 1999 Sep 23;42(19):3852-9
pubmed: 10508434
Bioorg Med Chem. 2007 Dec 15;15(24):7795-802
pubmed: 17888664
Signal Transduct Target Ther. 2020 Jul 29;5(1):131
pubmed: 32728018
Trends Biochem Sci. 2003 Jun;28(6):329-35
pubmed: 12826405
Chem Phys Lett. 2021 Jul;774:138618
pubmed: 33850334
Methods Mol Biol. 2019;2008:131-146
pubmed: 31124094
Int J Mol Sci. 2020 Aug 14;21(16):
pubmed: 32824072
Nucleic Acids Res. 2018 Sep 28;46(17):e104
pubmed: 29901763
Planta Med. 2006 Oct;72(12):1136-41
pubmed: 16924584
Nat Rev Neurosci. 2020 Jan;21(1):36-51
pubmed: 31804615
Theranostics. 2016 Jan 06;6(3):369-91
pubmed: 26909112
Mol Cell. 2018 Jul 19;71(2):244-255.e5
pubmed: 29983320
Nat Protoc. 2014 Feb;9(2):337-61
pubmed: 24434802
Curr Med Chem. 2005;12(19):2241-58
pubmed: 16178783
PLoS One. 2015 Jun 22;10(6):e0130062
pubmed: 26098995
ACS Chem Biol. 2016 Mar 18;11(3):583-97
pubmed: 26540123
Biochem J. 2021 Jul 16;478(13):2481-2497
pubmed: 34198328
Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7874-8
pubmed: 23794451
J Med Chem. 2021 Sep 9;64(17):12738-12760
pubmed: 34431664
Antiviral Res. 2014 Apr;104:156-64
pubmed: 24530452
Nature. 2010 Nov 18;468(7322):452-6
pubmed: 21085181
Curr Opin Struct Biol. 2002 Dec;12(6):783-93
pubmed: 12504684
Nucleic Acids Res. 2015 Feb 27;43(4):2242-58
pubmed: 25653167
J Biomol Struct Dyn. 2021 Aug;39(13):4582-4593
pubmed: 32567979
J Mol Biol. 1999 Jun 4;289(2):277-91
pubmed: 10366505
J Biol Chem. 1980 May 25;255(10):4387-90
pubmed: 6768721
SLAS Discov. 2021 Jul;26(6):757-765
pubmed: 33874769
Nat Rev Mol Cell Biol. 2019 Oct;20(10):608-624
pubmed: 31520073
J Am Chem Soc. 2013 Jan 23;135(3):1048-56
pubmed: 23244065
J Med Chem. 1974 Dec;17(12):1286-9
pubmed: 4473550
Cancer Chemother Pharmacol. 2003 Jul;52 Suppl 1:S80-9
pubmed: 12819937
Comput Biol Med. 2021 Jun;133:104359
pubmed: 33845270
Comb Chem High Throughput Screen. 2016;19(7):516-36
pubmed: 27151482
PLoS Pathog. 2013;9(8):e1003521
pubmed: 23935499
Nat Commun. 2021 May 11;12(1):2619
pubmed: 33976183
J Virol. 2015 Aug;89(16):8416-27
pubmed: 26041293
Antiviral Res. 2018 Jun;154:124-131
pubmed: 29680670
Cell. 2012 Mar 16;148(6):1089-98
pubmed: 22424221
Nucleic Acids Res. 2015 Oct 15;43(18):e117
pubmed: 26019180
Nature. 2019 Feb;566(7743):224-229
pubmed: 30728502
J Biomol Struct Dyn. 2021 Oct;39(17):6713-6727
pubmed: 32741322
Chembiochem. 2004 Mar 5;5(3):265-9
pubmed: 14997517
J Virol. 2014 Apr;88(8):4251-64
pubmed: 24478444
Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18527-32
pubmed: 19846791
J Biomol Struct Dyn. 2022 Feb;40(3):1331-1346
pubmed: 33016237
J Med Chem. 2015 May 14;58(9):4016-28
pubmed: 25909386
Gene Rep. 2020 Dec;21:100860
pubmed: 32875166
J Med Chem. 2019 Sep 12;62(17):7788-7805
pubmed: 31442049
J Biomol Struct Dyn. 2021 Aug;39(13):4633-4646
pubmed: 32573355
Nat Commun. 2018 Jul 17;9(1):2771
pubmed: 30018376
J Med Chem. 2019 Aug 8;62(15):7210-7232
pubmed: 31282680
Antimicrob Agents Chemother. 2020 Mar 24;64(4):
pubmed: 31964798
J Biomol Struct Dyn. 2021 Nov 12;:1-11
pubmed: 34766876
Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26
pubmed: 11259830
J Virol. 2017 Feb 14;91(5):
pubmed: 28031359
Nat Med. 2017 Nov;23(11):1369-1376
pubmed: 28920958
J Struct Funct Genomics. 2007 Sep;8(2-3):37-44
pubmed: 17588214
Nucleic Acids Res. 2009 Mar;37(4):e32
pubmed: 19181706
J Am Chem Soc. 2016 Dec 21;138(50):16212-16215
pubmed: 27998085
Wiley Interdiscip Rev RNA. 2021 Jul;12(4):e1639
pubmed: 33438329
RNA. 2010 Jan;16(1):211-20
pubmed: 19926722
Nucleic Acids Res. 2014 Aug;42(14):9350-65
pubmed: 25063302
J Biol Res (Thessalon). 2021 Aug 4;28(1):18
pubmed: 34344455
ACS Med Chem Lett. 2021 Jun 09;12(7):1102-1107
pubmed: 34257831
Front Oncol. 2021 Feb 25;10:612337
pubmed: 33718113
Chem Commun (Camb). 2020 Feb 18;56(14):2115-2118
pubmed: 31970375
Nat Chem. 2009 Jun;1(3):187-92
pubmed: 21378847
Trends Biochem Sci. 1991 Sep;16(9):323-6
pubmed: 1835191
SLAS Discov. 2021 Jul;26(6):749-756
pubmed: 33724070
Biochem Pharmacol. 1973 Feb 15;22(4):493-500
pubmed: 4570966
Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):
pubmed: 34045361
Chemistry. 2017 May 2;23(25):5988-5993
pubmed: 28042932
Org Lett. 2005 May 26;7(11):2141-4
pubmed: 15901154
Mol Cell. 2018 Feb 1;69(3):354-369
pubmed: 29395060
Anal Biochem. 2004 Mar 1;326(1):100-5
pubmed: 14769341
Acta Pharm Sin B. 2021 Mar;11(3):632-650
pubmed: 33777672
Biochimie. 1972;54(8):989-95
pubmed: 4569776
Chembiochem. 2012 May 29;13(8):1167-73
pubmed: 22549896
Angew Chem Int Ed Engl. 2017 Jun 1;56(23):6507-6510
pubmed: 28471013
Biochemistry. 1982 Mar 30;21(7):1535-41
pubmed: 6282307
Eur J Med Chem. 2019 Jan 1;161:323-333
pubmed: 30368131
Enzyme. 1979;24(6):353-7
pubmed: 391549
Nat Rev Drug Discov. 2011 Mar;10(3):188-95
pubmed: 21358738
Sci Adv. 2020 Aug 26;6(35):eaaz4551
pubmed: 32923617
J Gen Virol. 2010 Jan;91(Pt 1):112-21
pubmed: 19776234
Angew Chem Int Ed Engl. 2017 May 2;56(19):5182-5200
pubmed: 27943567
RNA Biol. 2014;11(12):1597-607
pubmed: 25626080
Sci Rep. 2017 May 9;7(1):1632
pubmed: 28487506
Curr Top Med Chem. 2018;18(28):2448-2457
pubmed: 30465505
Nat Commun. 2014;5:3004
pubmed: 24402442
Arch Biochem Biophys. 1989 Dec;275(2):334-43
pubmed: 2596846
Molecules. 2020 Sep 11;25(18):
pubmed: 32932762
J Mol Biol. 2009 Feb 6;385(5):1643-54
pubmed: 19101564
Nucleic Acids Res. 2005 Jul 18;33(13):3955-64
pubmed: 16027442
Chembiochem. 2012 Oct 15;13(15):2225-33
pubmed: 22961989
World Health Stat Q. 1992;45(2-3):292-8
pubmed: 1462664
Cancer Res. 1980 Aug;40(8 Pt 1):2701-5
pubmed: 6155997
Bioconjug Chem. 2018 Mar 21;29(3):686-701
pubmed: 29287474
J Am Chem Soc. 2014 Oct 1;136(39):13550-3
pubmed: 25170533
Nat Struct Biol. 2002 Mar;9(3):217-24
pubmed: 11836534
Antiviral Res. 2009 Jul;83(1):28-34
pubmed: 19501254
Eur J Med Chem. 2018 Sep 5;157:994-1004
pubmed: 30170321
Cancer Treat Rep. 1981;65 Suppl 3:3-9
pubmed: 7346154
Chem Soc Rev. 2010 Apr;39(4):1272-9
pubmed: 20349533
Beilstein J Org Chem. 2016 Dec 12;12:2694-2718
pubmed: 28144341
Antiviral Res. 2012 Oct;96(1):21-31
pubmed: 22841701
BMC Bioinformatics. 2007 Mar 05;8:73
pubmed: 17338813
Nat Microbiol. 2020 Jun;5(6):796-812
pubmed: 32367055
ACS Infect Dis. 2019 Mar 8;5(3):326-335
pubmed: 30682246
RNA Biol. 2012 May;9(5):577-86
pubmed: 22614835
Nat Cell Biol. 2019 May;21(5):552-559
pubmed: 31048770
J Biol Chem. 2005 Sep 16;280(37):32101-6
pubmed: 16046409
J Biol Chem. 2006 Nov 24;281(47):35904-13
pubmed: 16971388
Biochimie. 1976;58(1-2):201-5
pubmed: 782555
Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748):
pubmed: 29685976
Chem Biol Drug Des. 2011 Aug;78(2):199-210
pubmed: 21564555
J Pharm Sci. 1972 Apr;61(4):645-9
pubmed: 4552283
EMBO J. 2017 Apr 3;36(7):919-933
pubmed: 28254839
Genome Biol. 2012 Oct 31;13(10):175
pubmed: 23113984
J Virol. 2020 Jul 30;94(16):
pubmed: 32461321
J Biol Chem. 2010 Oct 15;285(42):32586-95
pubmed: 20685660
Anal Biochem. 2013 Dec 15;443(2):214-21
pubmed: 24018340
Nat Rev Cancer. 2020 Jun;20(6):303-322
pubmed: 32300195
J Genet Eng Biotechnol. 2021 Nov 9;19(1):172
pubmed: 34751829
Bioinformation. 2012;8(8):348-52
pubmed: 22570514
J Med Chem. 2013 Sep 26;56(18):7278-88
pubmed: 23981144
RNA. 2017 Mar;23(3):346-354
pubmed: 27932585
Cancer Res. 2009 Oct 15;69(20):8127-32
pubmed: 19808971
Nature. 2021 Sep;597(7877):566-570
pubmed: 34526715
Drugs. 2016 May;76(8):889-900
pubmed: 27193945
Nat Rev Microbiol. 2021 Mar;19(3):141-154
pubmed: 33024307
Biochemistry. 2004 Oct 26;43(42):13496-509
pubmed: 15491157
ACS Infect Dis. 2015 Aug 14;1(8):340-9
pubmed: 26726314
J Mol Graph Model. 2016 Sep;69:78-91
pubmed: 27588363
Front Bioeng Biotechnol. 2018 Apr 13;6:46
pubmed: 29707539
PLoS One. 2016 Jul 18;11(7):e0158923
pubmed: 27427769
J Biol Chem. 2005 May 27;280(21):20404-12
pubmed: 15760890
Virus Res. 2014 Dec 19;194:191-9
pubmed: 25278144
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3484-9
pubmed: 19208801
J Biol Chem. 2011 Feb 25;286(8):6233-40
pubmed: 21147775
J Biomol Screen. 2005 Jun;10(4):355-64
pubmed: 15964937
J Biomol Struct Dyn. 2021 May;39(8):2679-2692
pubmed: 32266873
Nat Commun. 2019 Dec 5;10(1):5540
pubmed: 31804488
Eur J Med Chem. 2017 Jan 5;125:865-880
pubmed: 27750202
J Virol. 2008 Aug;82(16):8071-84
pubmed: 18417574
Nat Rev Drug Discov. 2013 Jun;12(6):447-64
pubmed: 23722347
Nat Rev Microbiol. 2019 Mar;17(3):181-192
pubmed: 30531947
PLoS Pathog. 2011 May;7(5):e1002059
pubmed: 21637813
J Biol Chem. 1992 Jul 5;267(19):13314-9
pubmed: 1320016
Biochem Biophys Res Commun. 2021 Jan 22;537:71-77
pubmed: 33387885
PLoS Pathog. 2010 Apr 22;6(4):e1000863
pubmed: 20421945
Drug Discov Today. 2019 May;24(5):1148-1156
pubmed: 30851414
J Recept Signal Transduct Res. 2020 Dec;40(6):605-612
pubmed: 32476594
Genome Biol. 2017 Oct 23;18(1):197
pubmed: 29061143
Biochimie. 1973 May;55(5):541-6
pubmed: 4585175
Adv Ther. 2020 Jul;37(7):3059-3082
pubmed: 32445185
Chem Commun (Camb). 2014 May 4;50(34):4478-81
pubmed: 24664183
Life Sci. 2020 Oct 15;259:118169
pubmed: 32738360
ACS Infect Dis. 2021 Aug 13;7(8):2214-2220
pubmed: 34152728
RNA. 2011 Jul;17(7):1236-46
pubmed: 21602303
Antiviral Res. 2014 Jun;106:61-70
pubmed: 24704437
Structure. 1996 Nov 15;4(11):1263-75
pubmed: 8939751
Nature. 2016 May 25;534(7608):575-8
pubmed: 27281194
Curr Comput Aided Drug Des. 2011 Mar;7(1):10-22
pubmed: 20807187
Virus Res. 2012 Aug;167(2):322-8
pubmed: 22659295
PLoS Genet. 2017 May 24;13(5):e1006804
pubmed: 28542199
Angew Chem Int Ed Engl. 2021 Jan 4;60(1):480-485
pubmed: 33017502
Angew Chem Int Ed Engl. 1998 Nov 2;37(20):2888-2891
pubmed: 29711100
Clin Chem. 2000 Feb;46(2):265-72
pubmed: 10657384
J Biomol Struct Dyn. 2018 Apr;36(5):1118-1133
pubmed: 28351337
Biochim Biophys Acta. 1975 Apr 7;385(2):312-23
pubmed: 1092359
J Biomol Screen. 2014 Sep;19(8):1147-53
pubmed: 24793430
Chem Sci. 2017 Dec 1;8(12):7947-7953
pubmed: 29619168
Nucleic Acids Res. 2020 Aug 20;48(14):8099-8112
pubmed: 32602532
Biotechnol Lett. 2018 Feb;40(2):315-324
pubmed: 29063288
Nature. 2019 Jan;565(7740):500-504
pubmed: 30626973
Virus Res. 2018 Sep 2;256:209-218
pubmed: 29958924
Drug Dev Res. 2022 May;83(3):783-799
pubmed: 35040501
Nature. 2014 Sep 25;513(7519):481-3
pubmed: 25254460
Chemistry. 2017 May 2;23(25):6165-6173
pubmed: 27869340
J Biomol Screen. 2006 Aug;11(5):497-510
pubmed: 16760373
Nat Biotechnol. 2019 Jun;37(6):601-612
pubmed: 31133743
Nat Rev Genet. 2018 Feb;19(2):81-92
pubmed: 29033456
mSphere. 2017 Nov 15;2(6):
pubmed: 29152578
J Mol Biol. 2004 Mar 26;337(3):545-60
pubmed: 15019776
Elife. 2016 Sep 14;5:
pubmed: 27627798
Angew Chem Int Ed Engl. 2014 Apr 7;53(15):3965-9
pubmed: 24616228
J Med Chem. 1992 Nov 27;35(24):4576-83
pubmed: 1335077
Virology. 1983 Nov;131(1):18-29
pubmed: 6359667
Front Mol Biosci. 2020 Aug 05;7:180
pubmed: 32850968
Genome Res. 1999 Jan;9(1):17-26
pubmed: 9927481
Angew Chem Int Ed Engl. 2020 Feb 17;59(8):3161-3165
pubmed: 31747109
Proc Natl Acad Sci U S A. 2009 May 19;106(20):8180-5
pubmed: 19416846
Nat Rev Drug Discov. 2016 Sep;15(9):605-619
pubmed: 27417849
Arch Biochem Biophys. 1991 Feb 1;284(2):264-9
pubmed: 1989510
J Chem Inf Comput Sci. 2001 Sep-Oct;41(5):1308-15
pubmed: 11604031
Biochim Biophys Acta. 1978 Aug 23;520(1):153-63
pubmed: 698227
Mol Cell. 2011 Dec 23;44(6):997-1004
pubmed: 22195972
Biochemistry. 1977 Aug 23;16(17):3928-32
pubmed: 901760
ChemMedChem. 2020 May 6;15(9):744-748
pubmed: 32159918
Biochem Biophys Res Commun. 2017 Jan 29;483(1):687-693
pubmed: 27986564
Antiviral Res. 2008 Dec;80(3):360-9
pubmed: 18809436
RNA. 2006 Mar;12(3):488-97
pubmed: 16431985
J Biomol Struct Dyn. 2021 Nov 30;:1-13
pubmed: 34844519
Biochem Biophys Rep. 2021 Sep;27:101069
pubmed: 34250275
J Pharm Anal. 2021 Jun;11(3):272-277
pubmed: 32923004
Antiviral Res. 2013 Sep;99(3):292-300
pubmed: 23769894
J Biomol Struct Dyn. 2021 Feb 15;:1-11
pubmed: 33583328
Nucleic Acids Res. 2010 Mar;38(5):1652-63
pubmed: 20007606
PLoS One. 2011;6(8):e23168
pubmed: 21858014
Viruses. 2021 Jun 01;13(6):
pubmed: 34205979
iScience. 2021 Feb 19;24(2):102021
pubmed: 33426509
Methods Mol Biol. 2016;1439:47-63
pubmed: 27316987
J Biol Chem. 2004 Aug 20;279(34):35638-43
pubmed: 15152003
Angew Chem Int Ed Engl. 2018 May 22;57(21):6342-6346
pubmed: 29461645
J Antibiot (Tokyo). 1995 Nov;48(11):1273-9
pubmed: 8557568
Cell Rep. 2019 Mar 26;26(13):3762-3771.e5
pubmed: 30917327
J Enzyme Inhib Med Chem. 2021 Dec;36(1):727-736
pubmed: 33685335
SLAS Discov. 2021 Jun;26(5):620-627
pubmed: 33423577
Chem Phys Lett. 2021 May 16;771:138463
pubmed: 33716307
Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9436-41
pubmed: 26159422
Angew Chem Int Ed Engl. 2021 Feb 19;60(8):4098-4103
pubmed: 33095964
Gene. 1995 May 19;157(1-2):221-3
pubmed: 7541762
Pharmazie. 2006 Mar;61(3):247-8
pubmed: 16599271
J Proteome Res. 2020 Nov 6;19(11):4670-4677
pubmed: 32907334
Viruses. 2017 Apr 24;9(4):
pubmed: 28441781
ChemistryOpen. 2015 Jun;4(3):295-301
pubmed: 26246991
J Biol Chem. 1958 May;232(1):169-76
pubmed: 13549407
Phytother Res. 2021 Feb;35(2):908-919
pubmed: 32964551
FEBS Lett. 1973 Mar 1;30(2):177-180
pubmed: 11947088
J Pharm Bioallied Sci. 2016 Jul-Sep;8(3):188-94
pubmed: 27413346
Chembiochem. 2022 Jan 5;23(1):e202100437
pubmed: 34606675
ChemMedChem. 2021 Oct 6;16(19):3035-3043
pubmed: 34237194
Viruses. 2021 Mar 24;13(4):
pubmed: 33804957
ChemMedChem. 2008 Mar;3(3):435-44
pubmed: 18064617
J Biomol Struct Dyn. 2022 Jun;40(9):3899-3906
pubmed: 33252031
J Am Chem Soc. 2005 Oct 19;127(41):14136-7
pubmed: 16218579
Nat Chem Biol. 2006 Jan;2(1):31-2
pubmed: 16408089
FEBS Lett. 2020 Feb;594(4):678-694
pubmed: 31623018
Protein Eng Des Sel. 2015 Jun;28(6):179-86
pubmed: 25755274
J Vis Exp. 2010 Oct 19;(44):
pubmed: 21048666
Nat Protoc. 2006;1(4):1879-86
pubmed: 17487172
Chembiochem. 2013 May 27;14(8):950-3
pubmed: 23650044
J Virol. 2007 Apr;81(8):3891-903
pubmed: 17267492
Chem Rev. 2013 Jan 9;113(1):119-91
pubmed: 23256727