Autologous stem cell transplantation for multiple myeloma patients with chronic kidney disease: a safe and effective option.
Journal
Bone marrow transplantation
ISSN: 1476-5365
Titre abrégé: Bone Marrow Transplant
Pays: England
ID NLM: 8702459
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
10
08
2021
accepted:
22
03
2022
revised:
10
02
2022
pubmed:
14
4
2022
medline:
18
6
2022
entrez:
13
4
2022
Statut:
ppublish
Résumé
Chronic Kidney Disease (CKD) is a frequent complication in patients with multiple myeloma (MM) and is associated with adverse outcomes. The use of autologous stem cell transplantation (ASCT) has improved disease outcomes, however, the safety and efficacy of ASCT in patients with CKD has been the subject of debate. To investigate this, we conducted a retrospective analysis of 370 MM patients who underwent their first ASCT, including those with mild, moderate and severe CKD as well as normal renal function at the time of transplant. No significant difference in ASCT-related mortality, Progression-Free or Overall Survival was noted between the different renal function groups. A decline in estimated glomerular filtration rate (eGFR) at 1-year of >8.79% was associated with poorer overall survival (p < 0.001). The results of this study show that ASCT is a safe and effective option for myeloma patients with CKD, including those on dialysis. Patients who demonstrate renal deterioration at 1-year post-transplant should be closely monitored as this is a predictor for poor survival.
Identifiants
pubmed: 35413986
doi: 10.1038/s41409-022-01657-y
pii: 10.1038/s41409-022-01657-y
pmc: PMC9200631
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
959-965Informations de copyright
© 2022. The Author(s).
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