ARID1A expression in hepatocellular carcinoma and relation to tumor recurrence after microwave ablation.
ARID1A
hepatocellular carcinoma
microwave ablation
tumor recurrence
Journal
Clinical and experimental hepatology
ISSN: 2392-1099
Titre abrégé: Clin Exp Hepatol
Pays: Poland
ID NLM: 101703431
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
30
08
2021
accepted:
20
12
2021
entrez:
13
4
2022
pubmed:
14
4
2022
medline:
14
4
2022
Statut:
ppublish
Résumé
AT-rich interactive domain 1A (ARID1A) is a subunit of the switch/sucrose non-fermentable chromatin remodeling complex, which is commonly mutated in human cancers. The clinical and pathological significance of ARID1A alteration in hepatocellular carcinoma (HCC) has not yet been clarified. The present study aimed to evaluate the clinical significance of the ARID1A gene signature in HCC and its relation to the likelihood of tumor recurrence after microwave ablation (MWA). This study included 50 patients with cirrhotic HCC of Barcelona Clinic Liver Cancer stages 0/A eligible for MWA. Tumor and peri-tumor biopsies were obtained just prior to MWA and assessed for tumor pathological grade and ARID1A expression by immunohistochemistry. Patients were followed for one year after complete tumor ablation to detect any recurrence. Tumor size ( ARID1A loss may enhance HCC aggressiveness and post-MWA tumor recurrence. ARID1A could be a potential target to select HCC patients for future therapies.
Identifiants
pubmed: 35415261
doi: 10.5114/ceh.2022.114172
pii: 46516
pmc: PMC8984801
doi:
Types de publication
Journal Article
Langues
eng
Pagination
49-59Informations de copyright
Copyright © 2022 Clinical and Experimental Hepatology.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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