Stereospecific α-(hetero)arylation of sulfoximines and sulfonimidamides.
Journal
Nature synthesis
ISSN: 2731-0582
Titre abrégé: Nat Synth
Pays: England
ID NLM: 9918366786906676
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
entrez:
13
4
2022
pubmed:
14
4
2022
medline:
14
4
2022
Statut:
ppublish
Résumé
The occurrence of sulfoximines and sulfonimidoyl groups in biologically active molecules within pharmaceuticals and agrochemicals has notably increased in the past decade. This increase has prompted a wave of discovery of methods to install S(VI) functionality into complex organic molecules. Traditional synthetic methods to form α-substituted sulfonimidoyl motifs rely on S-C bond disconnections and typically require control of the stereogenic S-centre or late-stage modification at sulfur, and comprise multistep routes. Here, we report the development of a stereospecific, modular S
Identifiants
pubmed: 35415722
doi: 10.1038/s44160-021-00011-2
pmc: PMC8994872
mid: NIHMS1786803
doi:
Types de publication
Journal Article
Langues
eng
Pagination
170-179Subventions
Organisme : NCI NIH HHS
ID : P30 CA076292
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM142577
Pays : United States
Déclaration de conflit d'intérêts
Competing interests A provisional patent application naming J.M.L., Z.P.S., and T.S. as inventors has been filed by H. Lee Moffitt Cancer Center & Research Institute, which covers the synthetic methods for the α-(hetero)arylation of sulfonimidoyl functional groups. The remaining authors declare no competing interests.
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