Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test.
Journal
Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448
Informations de publication
Date de publication:
16 05 2022
16 05 2022
Historique:
pubmed:
14
4
2022
medline:
18
5
2022
entrez:
13
4
2022
Statut:
ppublish
Résumé
Despite the progress made in developmental toxicology, there is a great need for in vitro tests that identify developmental toxicants in relation to human oral doses and blood concentrations. In the present study, we established the hiPSC-based UKK2 in vitro test and analyzed genome-wide expression profiles of 23 known teratogens and 16 non-teratogens. Compounds were analyzed at the maximal plasma concentration (
Identifiants
pubmed: 35416653
doi: 10.1021/acs.chemrestox.1c00392
pmc: PMC9377669
doi:
Substances chimiques
Hazardous Substances
0
Teratogens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
760-773Références
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