Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
13 04 2022
13 04 2022
Historique:
received:
15
04
2020
accepted:
23
03
2022
entrez:
14
4
2022
pubmed:
15
4
2022
medline:
16
4
2022
Statut:
epublish
Résumé
Neuronal nerve processes in the tumor microenvironment were highlighted recently. However, the origin of intra-tumoral nerves remains poorly known, in part because of technical difficulties in tracing nerve fibers via conventional histological preparations. Here, we employ three-dimensional (3D) imaging of cleared tissues for a comprehensive analysis of sympathetic innervation in a murine model of pancreatic ductal adenocarcinoma (PDAC). Our results support two independent, but coexisting, mechanisms: passive engulfment of pre-existing sympathetic nerves within tumors plus an active, localized sprouting of axon terminals into non-neoplastic lesions and tumor periphery. Ablation of the innervating sympathetic nerves increases tumor growth and spread. This effect is explained by the observation that sympathectomy increases intratumoral CD163
Identifiants
pubmed: 35418199
doi: 10.1038/s41467-022-29659-w
pii: 10.1038/s41467-022-29659-w
pmc: PMC9007988
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1985Informations de copyright
© 2022. The Author(s).
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