CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis.
Autoantibodies
Autoimmune Diseases
Granulomatosis with polyangiitis
Inflammation
Systemic vasculitis
Journal
Annals of the rheumatic diseases
ISSN: 1468-2060
Titre abrégé: Ann Rheum Dis
Pays: England
ID NLM: 0372355
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
10
12
2021
accepted:
01
04
2022
pubmed:
15
4
2022
medline:
15
7
2022
entrez:
14
4
2022
Statut:
ppublish
Résumé
Myeloid cell activation by antineutrophil cytoplasmic antibody (ANCA) is pivotal for necrotising vasculitis, including necrotising crescentic glomerulonephritis (NCGN). In contrast to neutrophils, the contribution of classical monocyte (CM) and non-classical monocyte (NCM) remains poorly defined. We tested the hypothesis that CMs contribute to antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and that colony-stimulating factor-2 (CSF2, granulocyte-macrophage colony-stimulating factor (GM-CSF)) is an important monocyte-directed disease modifier. Myeloperoxidase (MPO)-immunised MPO Compared with WT mice, CCR2 CMs but not NCMs are important for inducing kidney damage in AAV. CSF2 is a crucial pathological factor by modulating monocyte proinflammatory functions and thereby T
Identifiants
pubmed: 35418479
pii: annrheumdis-2021-221984
doi: 10.1136/annrheumdis-2021-221984
pmc: PMC9279749
doi:
Substances chimiques
Antibodies, Antineutrophil Cytoplasmic
0
Granulocyte-Macrophage Colony-Stimulating Factor
83869-56-1
Peroxidase
EC 1.11.1.7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1162-1172Informations de copyright
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5172-81
pubmed: 27528685
Am J Pathol. 2005 Jul;167(1):39-45
pubmed: 15972950
J Am Soc Nephrol. 2015 Feb;26(2):411-24
pubmed: 25012177
Nat Rev Dis Primers. 2020 Aug 27;6(1):71
pubmed: 32855422
J Am Soc Nephrol. 2002 Feb;13(2):350-358
pubmed: 11805162
Nature. 2017 Jan 5;541(7635):96-101
pubmed: 28002407
Arthritis Rheum. 2001 Jul;44(7):1698-706
pubmed: 11465722
Blood. 1989 Nov 15;74(7):2527-34
pubmed: 2478233
J Leukoc Biol. 2002 Jun;71(6):996-1004
pubmed: 12050185
Cell. 1991 Sep 20;66(6):1175-84
pubmed: 1833065
J Am Soc Nephrol. 2005 Sep;16(9):2646-56
pubmed: 16033860
Nephrol Dial Transplant. 1999 Jul;14(7):1627-31
pubmed: 10435868
J Am Soc Nephrol. 2016 Sep;27(9):2906-16
pubmed: 26940094
Clin Exp Immunol. 2015 Jul;181(1):65-75
pubmed: 25766482
Immunity. 2013 Jan 24;38(1):79-91
pubmed: 23273845
J Am Soc Nephrol. 2012 Mar;23(3):470-82
pubmed: 22241891
Immunity. 2015 Sep 15;43(3):502-14
pubmed: 26341401
Autoimmun Rev. 2016 Nov;15(11):1046-1053
pubmed: 27491570
Sci Rep. 2015 Jul 07;5:11888
pubmed: 26149790
J Am Soc Nephrol. 2020 Sep;31(9):1996-2012
pubmed: 32616537
J Am Soc Nephrol. 2020 Jul;31(7):1569-1584
pubmed: 32487561
Science. 2017 Apr 21;356(6335):
pubmed: 28428369
Curr Opin Hematol. 2015 Jan;22(1):60-6
pubmed: 25394311
Immunity. 2016 Dec 20;45(6):1205-1218
pubmed: 28002729
Immunity. 2003 Jul;19(1):71-82
pubmed: 12871640
Immunity. 2016 Nov 15;45(5):963-973
pubmed: 27851925
Lancet. 1985 Jul 6;2(8445):48
pubmed: 2861500
Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5082-6
pubmed: 1828890
Nephrol Dial Transplant. 2016 Jun;31(6):930-6
pubmed: 26410887
Am J Pathol. 2017 Sep;187(9):1908-1915
pubmed: 28667835
JCI Insight. 2017 Jan 26;2(2):e87379
pubmed: 28138552
Nat Rev Nephrol. 2017 Oct;13(10):647-659
pubmed: 28781371
Semin Immunol. 2021 Apr;54:101518
pubmed: 34763973
Immunity. 2017 May 16;46(5):849-862.e7
pubmed: 28514690
Immunity. 2017 Nov 21;47(5):890-902.e4
pubmed: 29166589
J Am Soc Nephrol. 2020 Nov;31(11):2523-2542
pubmed: 32868399
J Lab Clin Med. 1995 Nov;126(5):495-502
pubmed: 7595035
N Engl J Med. 1988 Jun 23;318(25):1651-7
pubmed: 2453802