Estradiol inhibits HIV-1
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
13 04 2022
13 04 2022
Historique:
received:
27
09
2021
accepted:
30
03
2022
entrez:
14
4
2022
pubmed:
15
4
2022
medline:
16
4
2022
Statut:
epublish
Résumé
An inhibitory effect of estradiol (E2) on HIV-1 infection was suggested by several reports. We previously identified increased gene expression of actin-binding protein cofilin 1 (CFL1) in endocervix in the E2-dominated proliferative phase of the menstrual cycle. Actin cytoskeleton has an integral role in establishing and spreading HIV-1 infection. Herein, we studied in vitro effects of E2 on HIV-1 infection and on CFL1 expression to gain insight into the mechanism of HIV-1 inhibition by E2. E2 dose-dependently inhibited HIV-1
Identifiants
pubmed: 35418661
doi: 10.1038/s41598-022-10163-6
pii: 10.1038/s41598-022-10163-6
pmc: PMC9008051
doi:
Substances chimiques
CFL1 protein, human
0
Cofilin 1
0
Estradiol
4TI98Z838E
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6165Informations de copyright
© 2022. The Author(s).
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