Cell transcriptomic atlas of the non-human primate Macaca fascicularis.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
11
03
2021
accepted:
23
02
2022
pubmed:
15
4
2022
medline:
30
4
2022
entrez:
14
4
2022
Statut:
ppublish
Résumé
Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell-cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.
Identifiants
pubmed: 35418686
doi: 10.1038/s41586-022-04587-3
pii: 10.1038/s41586-022-04587-3
doi:
Substances chimiques
Receptors, Virus
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
723-731Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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