The Potential Role of Genomic Signature in Stage II Relapsed Colorectal Cancer (CRC) Patients: A Mono-Institutional Study.
NGS
biomarkers
colon cancer
next-generation sequencing
stage II
Journal
Cancer management and research
ISSN: 1179-1322
Titre abrégé: Cancer Manag Res
Pays: New Zealand
ID NLM: 101512700
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
12
2021
accepted:
21
02
2022
entrez:
14
4
2022
pubmed:
15
4
2022
medline:
15
4
2022
Statut:
epublish
Résumé
The absolute benefit of adjuvant chemotherapy in stage II CRC is only 3-4%. The identification of biomarkers through molecular profiling could identify patients who will more benefit from adjuvant chemotherapy. This retrospective analysis examined tissue blocks from 17 patients affected by relapsed stage II CRC, whose comprehensive genomic profiling of tumors was conducted through next-generation sequencing (NGS) via Roche-FoundationOne Mutations were found in APC (76.5%), TP53 (58.8%) and KRAS (52.9%). Only KRAS wild-type samples showed FBXW7. APC frameshift mutations and MLH1 splice variant were conversely significant correlated (7% v 93%, P = 0.014). The median number of gene mutations reported was 6 (range 2-14). The TP53 mutation was associated most frequently with lung metastasis (P = 0.07) and high tumor budding (P = 0.03). Despite no statistical significance, lung recurrence, LVI/Pni, MSI and more than 6 genetic mutations were correlated to worse DFS and OS. Patients carried co-mutations of TP53-FBXW7 reported the worse DFS (4 v 14 months) and OS (4 v 65 months) compared to the other patients. According to the present analysis, the setting of relapsed CRC emerges as one of the fields of greatest utility for NGS, looking at personalized cancer care.
Identifiants
pubmed: 35418781
doi: 10.2147/CMAR.S342612
pii: 342612
pmc: PMC9000544
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1353-1369Informations de copyright
© 2022 Roberto et al.
Déclaration de conflit d'intérêts
Prof. Dr. Andrea Laghi reports speaker’s fee from Bracco, from Bayer, from GE Healthcare, and from Guerbet, outside the submitted work. Prof. Dr. Paolo Marchetti reports grants, personal fees from ROCHE, grants, personal fees from MSD, grants, personal fees from BMS, grants from ASTRA ZENECA, grants from BOEHRINGER INGELHEIM, personal fees from LILLY, grants, personal fees from NOVARTIS, grants, personal fees from PFIZER, outside the submitted work. The authors report no other conflicts of interest in this work.
Références
Medicine (Baltimore). 2016 Feb;95(7):e2496
pubmed: 26886596
J Med Life. 2014 Oct-Dec;7(4):581-7
pubmed: 25713627
Mol Cancer. 2018 Aug 7;17(1):115
pubmed: 30086763
Dis Colon Rectum. 2008 May;51(5):503-7
pubmed: 18322753
Semin Oncol. 2011 Aug;38(4):511-20
pubmed: 21810510
Gut. 2002 Dec;51(6):797-802
pubmed: 12427779
Oncogenesis. 2019 Feb 19;8(3):13
pubmed: 30783098
Int J Mol Sci. 2017 Jan 06;18(1):
pubmed: 28067827
Mod Pathol. 2008 Nov;21(11):1403-12
pubmed: 18587323
Lancet Oncol. 2006 Jun;7(6):515-6
pubmed: 16750502
Br J Cancer. 2006 Feb 27;94(4):593-8
pubmed: 16421593
Nat Biotechnol. 2013 Nov;31(11):1023-31
pubmed: 24142049
Front Oncol. 2014 Mar 03;4:35
pubmed: 24624362
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6870-5
pubmed: 9618505
Ann Oncol. 2010 Apr;21(4):772-780
pubmed: 19833818
J Hum Genet. 2015 Oct;60(10):589-96
pubmed: 26134512
J Pathol Transl Med. 2018 Jan;52(1):37-44
pubmed: 29056035
World J Gastroenterol. 2015 Feb 7;21(5):1457-67
pubmed: 25663765
Br J Cancer. 2009 Jan 27;100(2):266-73
pubmed: 19165197
Am J Pathol. 2011 Mar;178(3):1387-94
pubmed: 21356388
J Am Coll Surg. 2010 May;210(5):767-76, 776-8
pubmed: 20421047
Oncotarget. 2010 Nov;1(7):651-61
pubmed: 21317460
J Clin Oncol. 2013 Oct 10;31(29):3664-72
pubmed: 24019539
Cancer Res. 2002 Aug 15;62(16):4535-9
pubmed: 12183400
Nature. 2011 Mar 3;471(7336):110-4
pubmed: 21368834
World J Gastroenterol. 2009 Dec 21;15(47):5898-906
pubmed: 20014453
Science. 1993 May 7;260(5109):816-9
pubmed: 8484122
Clin Cancer Res. 2004 Jan 15;10(2):433-9
pubmed: 14760062
J Natl Compr Canc Netw. 2018 Apr;16(4):359-369
pubmed: 29632055
Clin Cancer Res. 2020 Mar 1;26(5):1077-1085
pubmed: 31719050
Cancer Res. 2005 Dec 15;65(24):11361-6
pubmed: 16357143
J Thorac Dis. 2018 Nov;10(11):6147-6157
pubmed: 30622786
Mol Ther Methods Clin Dev. 2016 Apr 13;3:16024
pubmed: 27110583
Mol Cell Biol. 2012 Jun;32(11):2160-7
pubmed: 22473991
Carcinogenesis. 2015 Jul;36(7):710-8
pubmed: 25916654
Ann Surg Oncol. 2010 Aug;17(8):2066-72
pubmed: 20182809
Cancer Res. 2017 Jul 1;77(13):3527-3539
pubmed: 28522751
Biochim Biophys Acta. 2015 Jan;1855(1):104-21
pubmed: 25450577
Genes Chromosomes Cancer. 1999 Nov;26(3):247-52
pubmed: 10502323
Gastroenterology. 2005 Sep;129(3):837-45
pubmed: 16143123
Carcinogenesis. 2008 Sep;29(9):1765-73
pubmed: 18339680
Cancer. 2000 Apr 1;88(7):1739-57
pubmed: 10738234
Cancer Biol Ther. 2004 Jan;3(1):73-8
pubmed: 14726676
J Clin Pathol. 2003 Jan;56(1):69-73
pubmed: 12499439
Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7950-4
pubmed: 8755583
J Gastroenterol. 2006 Mar;41(3):185-92
pubmed: 16699851
Hum Mutat. 2003 Mar;21(3):192-200
pubmed: 12619105
Oncology. 2020;98(8):534-541
pubmed: 32235113
Br J Cancer. 2019 Apr;120(8):797-805
pubmed: 30894685
Eur J Cancer. 2009 Jul;45(10):1890-6
pubmed: 19427194
Oncogene. 1998 Dec 31;17(26):3471-7
pubmed: 10030671
Int J Cancer. 2010 Apr 15;126(8):1828-1837
pubmed: 19739118
J Clin Oncol. 2004 Aug 15;22(16):3408-19
pubmed: 15199089
Acta Oncol. 2014 Jul;53(7):852-64
pubmed: 24666267
Nature. 2002 Jun 27;417(6892):949-54
pubmed: 12068308
Pathol Res Pract. 2019 Mar;215(3):483-489
pubmed: 30611619
J Clin Oncol. 2009 Feb 20;27(6):872-7
pubmed: 19124803
Clin Cancer Res. 2015 Dec 1;21(23):5294-304
pubmed: 26187617
Clin Cancer Res. 2009 Nov 15;15(22):6956-62
pubmed: 19903786
Cancer Metastasis Rev. 2018 Mar;37(1):173-187
pubmed: 29322354
Clin Cancer Res. 2014 Jan 1;20(1):265-272
pubmed: 24170544
Genome Med. 2016 Jun 01;8(1):62
pubmed: 27245685
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
Lancet. 2007 Dec 15;370(9604):2020-9
pubmed: 18083404
N Engl J Med. 2004 Jun 3;350(23):2343-51
pubmed: 15175436
Nature. 1999 Apr 1;398(6726):422-6
pubmed: 10201372
Clin Cancer Res. 2011 Mar 1;17(5):1122-30
pubmed: 21239505
Cancer Res. 2007 Oct 1;67(19):9006-12
pubmed: 17909001
J Clin Pathol. 2016 Sep;69(9):767-71
pubmed: 26797410
Lancet Oncol. 2006 Jun;7(6):516-7
pubmed: 16767832
J Mol Diagn. 2017 Jan;19(1):4-23
pubmed: 27993330
J Exp Med. 2011 Feb 14;208(2):295-312
pubmed: 21282377
Mol Cancer Res. 2016 Nov;14(11):1097-1109
pubmed: 27470268
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613
pubmed: 30476243
N Engl J Med. 1988 Sep 1;319(9):525-32
pubmed: 2841597
Gan To Kagaku Ryoho. 2013 Nov;40(12):1650-2
pubmed: 24393877
Int J Cancer. 2010 Jul 15;127(2):367-80
pubmed: 19908233
Nat Rev Cancer. 2003 May;3(5):330-8
pubmed: 12724731
Oncogene. 1999 Dec 20;18(55):7860-72
pubmed: 10630639
Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9433-8
pubmed: 12093899
PLoS One. 2014 Feb 19;9(2):e89388
pubmed: 24586741
Oncotarget. 2017 Jun 13;8(24):39268-39279
pubmed: 28424412
J Clin Oncol. 2006 Sep 1;24(25):4078-84
pubmed: 16943525
Proc Natl Acad Sci U S A. 1995 May 23;92(11):5067-71
pubmed: 7761449
World J Surg. 2019 Dec;43(12):3207-3215
pubmed: 31515570
Oncogene. 2017 Feb 9;36(6):787-796
pubmed: 27399335
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
Clin Cancer Res. 2013 Jun 15;19(12):3285-96
pubmed: 23633456
World J Gastrointest Oncol. 2019 Jul 15;11(7):551-566
pubmed: 31367274
J Clin Oncol. 2011 Apr 1;29(10):1261-70
pubmed: 21383284
J Int Med Res. 2019 May;47(5):1829-1842
pubmed: 30616445
Gut. 2005 Sep;54(9):1283-6
pubmed: 15843421
J Surg Oncol. 2003 Nov;84(3):127-31
pubmed: 14598355
Int J Colorectal Dis. 2019 May;34(5):905-913
pubmed: 30915540
Science. 2000 Aug 18;289(5482):1194-7
pubmed: 10947987
Arch Pathol Lab Med. 2000 Jul;124(7):979-94
pubmed: 10888773
Ann Oncol. 2009 Jul;20(7):1216-22
pubmed: 19164452
Am J Pathol. 2000 May;156(5):1773-9
pubmed: 10793088
Nat Genet. 2006 Jul;38(7):787-93
pubmed: 16804544
Oncotarget. 2016 Nov 8;7(45):73876-73887
pubmed: 27729614
Science. 1998 Sep 4;281(5382):1509-12
pubmed: 9727977
J Natl Cancer Inst. 2016 Dec 31;109(5):
pubmed: 28040692
Cancer Res. 1993 Dec 15;53(24):5849-52
pubmed: 8261392
Clin Cancer Res. 2009 Jul 15;15(14):4665-73
pubmed: 19584150
Neoplasia. 2006 Jun;8(6):458-64
pubmed: 16820091
Eur J Cancer. 2000 Dec;36(18):2294-300
pubmed: 11094302
Cancer Med. 2016 Feb;5(2):256-64
pubmed: 26715198