Autonomic Nervous System Dysregulation and Osteoarthritis Pain: Mechanisms, Measurement, and Future Outlook.
Autonomic nervous system
Neuro-immune axis
Osteoarthritis
Pain
Journal
Current rheumatology reports
ISSN: 1534-6307
Titre abrégé: Curr Rheumatol Rep
Pays: United States
ID NLM: 100888970
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
accepted:
11
03
2022
pubmed:
15
4
2022
medline:
14
6
2022
entrez:
14
4
2022
Statut:
ppublish
Résumé
The autonomic nervous system is an important regulator of stress responses and exhibits functional changes in chronic pain states. This review discusses potential overlap among autonomic dysregulation, osteoarthritis (OA) progression, and chronic pain. From this foundation, we then discuss preclinical to clinical research opportunities to close gaps in our knowledge of autonomic dysregulation and OA. Finally, we consider the potential to generate new therapies for OA pain via modulation of the autonomic nervous system. Recent reviews provide a framework for the autonomic nervous system in OA progression; however, research is still limited on the topic. In other chronic pain states, functional overlaps between the central autonomic network and pain processing centers in the brain suggest relationships between concomitant dysregulation of the two systems. Non-pharmacological therapeutics, such as vagus nerve stimulation, mindfulness-based meditation, and exercise, have shown promise in alleviating painful symptoms of joint diseases, and these interventions may be partially mediated through the autonomic nervous system. The autonomic nervous system appears to be dysregulated in OA progression, and further research on rebalancing autonomic function may lead to novel therapeutic strategies for treating OA pain.
Identifiants
pubmed: 35420372
doi: 10.1007/s11926-022-01071-9
pii: 10.1007/s11926-022-01071-9
pmc: PMC9189055
mid: NIHMS1798787
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
175-183Subventions
Organisme : NIAMS NIH HHS
ID : F31 AR077996
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR071431
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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