The Fused Methionine Sulfoxide Reductase MsrAB Promotes Oxidative Stress Defense and Bacterial Virulence in Fusobacterium nucleatum.
Fusobacterium nucleatum
MsrAB
adherence
cell invasion
gene regulation
oxidative stress
preterm birth
virulence
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
28 06 2022
28 06 2022
Historique:
pubmed:
15
4
2022
medline:
1
7
2022
entrez:
14
4
2022
Statut:
ppublish
Résumé
Fusobacterium nucleatum, an anaerobic Gram-negative bacterium frequently found in the human oral cavity and some extra-oral sites, is implicated in several important diseases: periodontitis, adverse pregnancy outcomes, and colorectal cancer. To date, how this obligate anaerobe copes with oxidative stress and host immunity within multiple human tissues remains unknown. Here, we uncovered a critical role in this process of a multigene locus encoding a single, fused methionine sulfoxide reductase (MsrAB), a two-component signal transduction system (ModRS), and thioredoxin (Trx)- and cytochrome
Identifiants
pubmed: 35420473
doi: 10.1128/mbio.03022-21
pmc: PMC9239216
doi:
Substances chimiques
Carrier Proteins
0
Reactive Oxygen Species
0
Thioredoxins
52500-60-4
Cytochromes c
9007-43-6
Methionine Sulfoxide Reductases
EC 1.8.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0302221Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE026758
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE030895
Pays : United States
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