Protective effect of polysaccharides from Ostrea rivularis against reproductive injury via regulating autophagy induced by oxidative stress.

Animals Autophagy Crassostrea Hydrogen Peroxide / toxicity Male Ostrea Oxidative Stress Polysaccharides / pharmacology
Autophagy Polysaccharide from Ostrea rivularis Gould Reproductive oxidative stress damage

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
01 Jun 2022
Historique:
received: 19 01 2022
revised: 06 04 2022
accepted: 06 04 2022
pubmed: 15 4 2022
medline: 18 5 2022
entrez: 14 4 2022
Statut: ppublish

Résumé

The objective of this study was to investigate the effect of polysaccharides from Ostrea rivularis (ORP) relieving reproductive damage by regulating autophagy. The results showed that ORP intervention could alleviate the pathological changes of the testis and alleviate oxidative stress which were caused by cyclophosphamide (CTX) in vivo, including improve sperm symptoms and rise testosterone level. Reduced level of autophagy after ORP intervention was observed by transmission electron microscopy (TEM), which implied that ORP might regulate cell autophagy. In vitro experiments showed that ORP could alleviate the damage of TM4 cells induced by H

Identifiants

DOI: 10.1016/j.ijbiomac.2022.04.053 PMID: 35421415
pubmed: 35421415
pii: S0141-8130(22)00750-4
doi: 10.1016/j.ijbiomac.2022.04.053
pii:
doi:

Substances chimiques

Polysaccharides 0
Hydrogen Peroxide BBX060AN9V

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

655-667

Informations de copyright

Copyright © 2022. Published by Elsevier B.V.

Auteurs

Tian Yu (T)

Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China; South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China.

Xianying Ye (X)

Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China; South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China.

Fang Deng (F)

First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China.

Zhuoyue Song (Z)

Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China; South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China; School of Chinese Medicine, Chinese University of Hong Kong, Hong Kong 999077, PR China.

Mengru Zhu (M)

Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China; South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China.

Yao Chen (Y)

Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China; South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China.

Tao Liu (T)

Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China; South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China.

Shihui Liu (S)

Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China; South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China. Electronic address: liushihui@gzucm.edu.cn.

Shijie Li (S)

Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China; South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China. Electronic address: lisj666@163.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Protective effect of polysaccharides from...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Protective effect of polysaccharides from...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Mollusca › Bivalvia › Ostreidae › Crassostrea › Protective effect of polysaccharides from...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Protective effect of polysaccharides from...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Mollusca › Bivalvia › Ostreidae › Ostrea › Protective effect of polysaccharides from...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Protective effect of polysaccharides from...
questionsmedicales.fr › Glucides › Polyosides › Protective effect of polysaccharides from...