PINK1-mediated Drp1

Animals Dynamins / genetics Mice Mice, Knockout Mitochondria / genetics Mitochondrial Dynamics / genetics Phosphorylation / genetics Protein Kinases / genetics

Journal

Signal transduction and targeted therapy
ISSN: 2059-3635
Titre abrégé: Signal Transduct Target Ther
Pays: England
ID NLM: 101676423

Informations de publication

Date de publication:
15 04 2022
Historique:
received: 21 09 2021
accepted: 14 02 2022
revised: 09 02 2022
entrez: 15 4 2022
pubmed: 16 4 2022
medline: 19 4 2022
Statut: epublish

Résumé

Dynamic change of mitochondrial morphology and distribution along neuronal branches are essential for neural circuitry formation and synaptic efficacy. However, the underlying mechanism remains elusive. We show here that Pink1 knockout (KO) mice display defective dendritic spine maturation, reduced axonal synaptic vesicles, abnormal synaptic connection, and attenuated long-term synaptic potentiation (LTP). Drp1 activation via S616 phosphorylation rescues deficits of spine maturation in Pink1 KO neurons. Notably, mice harboring a knockin (KI) phosphor-null Drp1

Identifiants

DOI: 10.1038/s41392-022-00933-z PMID: 35422062 PMC: PMC9010405
pubmed: 35422062
doi: 10.1038/s41392-022-00933-z
pii: 10.1038/s41392-022-00933-z
pmc: PMC9010405
doi:

Substances chimiques

Protein Kinases EC 2.7.-
PTEN-induced putative kinase EC 2.7.11.1
Dynamins EC 3.6.5.5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

103

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK002001
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK002001
Pays : United States

Informations de copyright

© 2022. The Author(s).

Références

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14503-8
pubmed: 18799731
J Neurosci. 1995 Jun;15(6):4328-42
pubmed: 7540672
EMBO Rep. 2007 Oct;8(10):939-44
pubmed: 17721437
J Clin Invest. 2009 Mar;119(3):650-60
pubmed: 19229105
J Mol Neurosci. 2019 Dec;69(4):570-579
pubmed: 31486971
Cell Rep. 2019 Jul 23;28(4):1015-1028.e5
pubmed: 31340140
Exp Mol Med. 2014 Jul 11;46:e105
pubmed: 25012575
J Neurosci. 2009 Oct 14;29(41):13019-29
pubmed: 19828815
Neuron. 2008 Dec 10;60(5):748-66
pubmed: 19081372
Cell Death Dis. 2015 Apr 16;6:e1725
pubmed: 25880092
Am J Anat. 1970 Apr;127(4):321-55
pubmed: 4985058
Nat Rev Mol Cell Biol. 2011 Jan;12(1):9-14
pubmed: 21179058
Neuron. 2017 Dec 20;96(6):1327-1341.e6
pubmed: 29268097
Neuron. 2012 Sep 6;75(5):762-77
pubmed: 22958818
Nat Commun. 2013;4:2550
pubmed: 24096541
J Cell Biol. 2014 Mar 31;204(7):1087-98
pubmed: 24687278
J Biol Chem. 2014 Dec 26;289(52):36179-93
pubmed: 25336659
J Biol Chem. 2009 Aug 21;284(34):22938-51
pubmed: 19546216
Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1638-43
pubmed: 18230723
Neuron. 2017 Mar 22;93(6):1405-1419.e8
pubmed: 28285821
Hum Mol Genet. 2011 Aug 15;20(16):3227-40
pubmed: 21613270
Neuron. 2018 Nov 21;100(4):860-875.e7
pubmed: 30318410
Cell. 2019 Jan 10;176(1-2):73-84.e15
pubmed: 30612742
Neuron. 2020 Feb 5;105(3):522-533.e4
pubmed: 31806492
Trends Neurosci. 2014 Jun;37(6):315-24
pubmed: 24735649
Annu Rev Neurosci. 2008;31:47-67
pubmed: 18284372
Nat Cell Biol. 2009 Aug;11(8):958-66
pubmed: 19578372
EMBO Rep. 2020 Aug 5;21(8):e48686
pubmed: 32484300
J Neurosci. 2011 Nov 2;31(44):15716-26
pubmed: 22049414
J Vis Exp. 2011 Jan 24;(47):
pubmed: 21304471
J Neurophysiol. 1995 Jan;73(1):270-9
pubmed: 7714571
Nat Rev Mol Cell Biol. 2010 Dec;11(12):872-84
pubmed: 21102612
Methods Mol Biol. 2019;1874:169-178
pubmed: 30353513
J Neurosci. 1993 Feb;13(2):568-76
pubmed: 8381168
Adv Exp Med Biol. 2017;1016:75-90
pubmed: 29130154
Cell. 2004 Dec 17;119(6):873-87
pubmed: 15607982
Nat Rev Neurosci. 2004 Jan;5(1):24-34
pubmed: 14708001
Annu Rev Physiol. 2019 Feb 10;81:1-17
pubmed: 30256725
Science. 2004 May 21;304(5674):1158-60
pubmed: 15087508
Mol Psychiatry. 2018 Feb;23(2):199-210
pubmed: 27671476
J Biol Chem. 2007 Apr 13;282(15):11521-9
pubmed: 17301055
Nat Commun. 2018 Nov 27;9(1):5008
pubmed: 30479337
J Biol Chem. 2009 May 15;284(20):13843-13855
pubmed: 19279012
J Cell Sci. 2017 Feb 15;130(4):671-681
pubmed: 28154157
Br J Pharmacol. 2006 Jan;147(2):199-208
pubmed: 16284628
Proc Natl Acad Sci U S A. 2008 May 13;105(19):7070-5
pubmed: 18443288
J Biol Chem. 2016 Oct 7;291(41):21616-21629
pubmed: 27528605
Nat Commun. 2017 Jun 26;8(1):31
pubmed: 28652625
Nat Commun. 2015 Apr 10;6:6789
pubmed: 25858512
Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12920-4
pubmed: 21768365

Auteurs

Qingtao Gao (Q)

Institute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410008, China.

Runyi Tian (R)

Institute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410008, China.

Hailong Han (H)

Institute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410008, China.

Jesse Slone (J)

Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, 14203, USA.

Caifang Wang (C)

Institute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410008, China.

Xiao Ke (X)

Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
The Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.

Tongmei Zhang (T)

Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
The Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.

Xiangyu Li (X)

Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, Hunan, 410008, China.

Yuhong He (Y)

Institute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410008, China.

Panlin Liao (P)

Institute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410008, China.

Fang Wang (F)

Department of Neurosciences, University of South China Medical School, Hengyang, Hunan, 421001, China.

Ye Chen (Y)

Institute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410008, China.

Shiqing Fu (S)

Department of Neurosciences, University of South China Medical School, Hengyang, Hunan, 421001, China.

Kexuan Zhang (K)

Institute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410008, China.

Fangfang Zeng (F)

Institute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410008, China.

Yingxuan Yang (Y)

Institute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410008, China.

Zhuo Li (Z)

Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, Hunan, 410008, China.

Jieqiong Tan (J)

Institute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410008, China.

Jiada Li (J)

Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, Hunan, 410008, China.

Youming Lu (Y)

Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
The Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.

Taosheng Huang (T)

Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, 14203, USA.

Zhonghua Hu (Z)

Institute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410008, China. huzhonghua@csu.edu.cn.
Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, Hunan, 410008, China. huzhonghua@csu.edu.cn.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. huzhonghua@csu.edu.cn.
Department of Critical Care Medicine, Hunan Provincial Clinical Research Center for Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. huzhonghua@csu.edu.cn.
ORCID: 0000-0002-0117-7081

Zhuohua Zhang (Z)

Institute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410008, China. zhangzhuohua@sklmg.edu.cn.
Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, Hunan, 410008, China. zhangzhuohua@sklmg.edu.cn.
Department of Neurosciences, University of South China Medical School, Hengyang, Hunan, 421001, China. zhangzhuohua@sklmg.edu.cn.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. zhangzhuohua@sklmg.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › PINK1-mediated Drp1
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Dynamines › PINK1-mediated Drp1
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › PINK1-mediated Drp1
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › PINK1-mediated Drp1
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › PINK1-mediated Drp1
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Renouvellement des mitochondries › Dynamique mitochondriale › PINK1-mediated Drp1
questionsmedicales.fr › Métabolisme › Phosphorylation › PINK1-mediated Drp1
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Protein kinases › PINK1-mediated Drp1