Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis.
Journal
Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
17
12
2021
revised:
04
04
2022
accepted:
04
04
2022
entrez:
15
4
2022
pubmed:
16
4
2022
medline:
19
4
2022
Statut:
epublish
Résumé
Max is an obligate dimerization partner for the Myc transcription factors and for several repressors, such as Mnt, Mxd1-4, and Mga, collectively thought to antagonize Myc function in transcription and oncogenesis. Mga, in particular, is part of the variant Polycomb group repressive complex PRC1.6. Here, we show that ablation of the distinct PRC1.6 subunit Pcgf6-but not Mga-accelerates Myc-induced lymphomagenesis in Eµ-
Identifiants
pubmed: 35422437
pii: 5/8/e202101344
doi: 10.26508/lsa.202101344
pmc: PMC9012912
pii:
doi:
Substances chimiques
Myc protein, mouse
0
Pcgf6 protein, mouse
0
Polycomb-Group Proteins
0
Proto-Oncogene Proteins c-myc
0
Polycomb Repressive Complex 1
EC 2.3.2.27
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022 Tanaskovic et al.
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