Breathing Abnormalities During Sleep and Wakefulness in Rett Syndrome: Clinical Relevance and Paradoxical Relationship With Circulating Pro-oxidant Markers.
Rett syndrome
non-protein-bound iron
oxidative stress
respiratory dysfunction
sleep-wakefulness cycle
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
12
2021
accepted:
02
02
2022
entrez:
15
4
2022
pubmed:
16
4
2022
medline:
16
4
2022
Statut:
epublish
Résumé
Breathing abnormalities are common in Rett syndrome (RTT), a pervasive neurodevelopmental disorder almost exclusively affecting females. RTT is linked to mutations in the methyl-CpG-binding protein 2 ( Female patients with a clinical diagnosis of typical RTT ( Significant prevalence of obstructive apneas with values of AHI > 15 was present in 69.7% of the population with RTT. The group with SA showed significantly increased AHI values > 15 ( Our findings indicate that the impact of apneas in RTT is uneven according to the sleep-wakefulness cycle, and that plasma redox active iron represents a potential novel therapeutic target.
Sections du résumé
Background
UNASSIGNED
Breathing abnormalities are common in Rett syndrome (RTT), a pervasive neurodevelopmental disorder almost exclusively affecting females. RTT is linked to mutations in the methyl-CpG-binding protein 2 (
Methods
UNASSIGNED
Female patients with a clinical diagnosis of typical RTT (
Results
UNASSIGNED
Significant prevalence of obstructive apneas with values of AHI > 15 was present in 69.7% of the population with RTT. The group with SA showed significantly increased AHI values > 15 (
Conclusion
UNASSIGNED
Our findings indicate that the impact of apneas in RTT is uneven according to the sleep-wakefulness cycle, and that plasma redox active iron represents a potential novel therapeutic target.
Identifiants
pubmed: 35422749
doi: 10.3389/fneur.2022.833239
pmc: PMC9001904
doi:
Types de publication
Journal Article
Langues
eng
Pagination
833239Informations de copyright
Copyright © 2022 Leoncini, Signorini, Boasiako, Scandurra, Hayek, Ciccoli, Rossi, Canitano and De Felice.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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