DNA Methyltransferase 3b Accelerates the Process of Atherosclerosis.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
01
2022
accepted:
09
03
2022
entrez:
15
4
2022
pubmed:
16
4
2022
medline:
19
4
2022
Statut:
epublish
Résumé
DNA methylation plays a key role in establishing cell type-specific gene expression profiles and patterns in atherosclerosis. The underlying mechanism remains unclear. Previous studies have shown that DNA methyltransferase 3b (DNMT3b) may play an important role in atherosclerosis. This study aimed to establish the regulatory role of DNMT3b in the development of atherosclerosis. We constructed a viral vector carrying Dnmt3b shRNA to transduce ApoE It showed that Dnmt3b silencing attenuated atherosclerosis, including decreased lesion size and macrophage content and increased collagen and smooth muscle cells content in ApoE DNMT3b accelerated atherosclerosis, and may be associated with FOXP3 hypermethylation status in regulatory T cells.
Sections du résumé
Background
UNASSIGNED
DNA methylation plays a key role in establishing cell type-specific gene expression profiles and patterns in atherosclerosis. The underlying mechanism remains unclear. Previous studies have shown that DNA methyltransferase 3b (DNMT3b) may play an important role in atherosclerosis. This study aimed to establish the regulatory role of DNMT3b in the development of atherosclerosis.
Methods
UNASSIGNED
We constructed a viral vector carrying Dnmt3b shRNA to transduce ApoE
Results
UNASSIGNED
It showed that Dnmt3b silencing attenuated atherosclerosis, including decreased lesion size and macrophage content and increased collagen and smooth muscle cells content in ApoE
Conclusions
UNASSIGNED
DNMT3b accelerated atherosclerosis, and may be associated with FOXP3 hypermethylation status in regulatory T cells.
Identifiants
pubmed: 35422896
doi: 10.1155/2022/5249367
pmc: PMC9005271
doi:
Substances chimiques
Apolipoproteins E
0
Forkhead Transcription Factors
0
RNA, Small Interfering
0
DNA (Cytosine-5-)-Methyltransferases
EC 2.1.1.37
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5249367Informations de copyright
Copyright © 2022 Ling Zhu et al.
Déclaration de conflit d'intérêts
All the authors declare there is no conflict of interest.
Références
Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3336-41
pubmed: 15728362
Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1936-42
pubmed: 23723375
J Immunol. 2009 Jan 1;182(1):259-73
pubmed: 19109157
Nat Med. 2006 Feb;12(2):178-80
pubmed: 16462800
J Immunol Res. 2018 Apr 15;2018:4973964
pubmed: 29850630
Blood. 2009 Oct 29;114(18):3727-35
pubmed: 19641188
J Clin Invest. 2014 Jul;124(7):3187-99
pubmed: 24865430
J Biomed Sci. 2014 Feb 03;21:11
pubmed: 24490960
Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):541-6
pubmed: 22190484
Epigenomics. 2015;7(2):247-65
pubmed: 25942534
Immunol Lett. 2011 Sep 30;139(1-2):7-13
pubmed: 21621552
Nat Immunol. 2011 Mar;12(3):204-12
pubmed: 21321594
Nat Rev Immunol. 2007 Apr;7(4):305-10
pubmed: 17380159
Trends Biochem Sci. 2014 Jul;39(7):310-8
pubmed: 24947342
Immunology. 2014 Jul;142(3):384-95
pubmed: 24476360
Hypertension. 2019 Sep;74(3):581-589
pubmed: 31327269
Nutr Metab (Lond). 2020 May 27;17:41
pubmed: 32508962
Exp Cell Res. 2016 Sep 10;347(1):95-104
pubmed: 27426728
Circ Res. 2014 Jun 20;115(1):32-43
pubmed: 24755985
Cardiovasc Res. 2009 Oct 1;84(1):155-63
pubmed: 19502284
Redox Biol. 2020 May;32:101444
pubmed: 32067910
Front Immunol. 2016 Nov 08;7:488
pubmed: 27877174
J Cell Physiol. 2020 Mar;235(3):2102-2112
pubmed: 31338841
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5289-94
pubmed: 24706905
N Engl J Med. 2005 Apr 21;352(16):1685-95
pubmed: 15843671
Hum Mol Genet. 2000 Oct;9(16):2395-402
pubmed: 11005794
FASEB J. 2006 Apr;20(6):782-4
pubmed: 16478769
J Mol Cell Cardiol. 2020 Jan;138:34-48
pubmed: 31733201
Nature. 2015 Jan 15;517(7534):321-6
pubmed: 25592537
Atherosclerosis. 2013 Jun;228(2):346-52
pubmed: 23566804