Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine.


Journal

RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657

Informations de publication

Date de publication:
14 Jan 2021
Historique:
received: 17 09 2020
accepted: 08 12 2020
entrez: 15 4 2022
pubmed: 18 1 2021
medline: 18 1 2021
Statut: epublish

Résumé

Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.

Identifiants

pubmed: 35424306
doi: 10.1039/d0ra07965k
pii: d0ra07965k
pmc: PMC8694183
doi:

Types de publication

Journal Article

Langues

eng

Pagination

3534-3538

Informations de copyright

This journal is © The Royal Society of Chemistry.

Déclaration de conflit d'intérêts

There are no conflicts to declare.

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Auteurs

Moran Frenkel-Pinter (M)

NSF/NASA Center for Chemical Evolution USA loren.williams@chemistry.gatech.edu.
School of Chemistry & Biochemistry, Georgia Institute of Technology Atlanta GA 30332 USA.
NASA Center for the Origins of Life, Georgia Institute of Technology Atlanta GA 30332 USA.

Alyssa B Sargon (AB)

NSF/NASA Center for Chemical Evolution USA loren.williams@chemistry.gatech.edu.
School of Chemistry & Biochemistry, Georgia Institute of Technology Atlanta GA 30332 USA.

Jennifer B Glass (JB)

NASA Center for the Origins of Life, Georgia Institute of Technology Atlanta GA 30332 USA.
School of Earth and Atmospheric Science, Georgia Institute of Technology Atlanta GA 30332 USA.

Nicholas V Hud (NV)

NSF/NASA Center for Chemical Evolution USA loren.williams@chemistry.gatech.edu.
School of Chemistry & Biochemistry, Georgia Institute of Technology Atlanta GA 30332 USA.
NASA Center for the Origins of Life, Georgia Institute of Technology Atlanta GA 30332 USA.

Loren Dean Williams (LD)

NSF/NASA Center for Chemical Evolution USA loren.williams@chemistry.gatech.edu.
School of Chemistry & Biochemistry, Georgia Institute of Technology Atlanta GA 30332 USA.
NASA Center for the Origins of Life, Georgia Institute of Technology Atlanta GA 30332 USA.

Classifications MeSH