Autoimmune Bullous Dermatosis Following COVID-19 Vaccination: A Series of Five Cases.
autoimmune bullous dermatosis
bullous pemphigoid
covid-19 vaccine
immunology
imputability
pemhigus vulgaris
superficial pemphigus
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
accepted:
13
03
2022
entrez:
15
4
2022
pubmed:
16
4
2022
medline:
16
4
2022
Statut:
epublish
Résumé
Autoimmune bullous diseases (AIBDs) are a heterogeneous group of diseases characterized by cutaneous and mucosal vesicles, blisters, and erosions. Several factors can trigger this disease, including vaccines; but this entity remains very rare. We hypothesized that vaccination against coronavirus disease 2019 (COVID-19) could trigger an immunological response in genetically predisposed individuals. We report five cases of new-onset autoimmune bullous diseases triggered by the COVID-19 vaccine. Clinical and histopathological examinations confirmed the diagnosis of bullous pemphigoid (BP) in three patients and pemphigus in the other two. According to the French method of imputability, the pharmacovigilance investigation showed an I5B4 causality assessment score for the vaccines, interpreted as highly probable, for all the patients. The diagnosis of vaccine-induced autoimmune bullous dermatosis was highly suspected. One patient's condition improved by dermocorticoids alone, while the other four required oral corticosteroid therapy at 0.5 mg/kg/day, which led to a favorable outcome.
Identifiants
pubmed: 35425676
doi: 10.7759/cureus.23127
pmc: PMC9004698
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e23127Informations de copyright
Copyright © 2022, Hali et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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