Modeling and Optimization of a Molecular Biocontroller for the Regulation of Complex Metabolic Pathways.
biomolecular antithetic controller
dynamic regulation
extended biosensor
gene circuit parts
metabolic pathway
modeling biological systems
multiobjective optimization
tuning
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
10
2021
accepted:
22
02
2022
entrez:
15
4
2022
pubmed:
16
4
2022
medline:
16
4
2022
Statut:
epublish
Résumé
Achieving optimal production in microbial cell factories, robustness against changing intracellular and environmental perturbations requires the dynamic feedback regulation of the pathway of interest. Here, we consider a merging metabolic pathway motif, which appears in a wide range of metabolic engineering applications, including the production of phenylpropanoids among others. We present an approach to use a realistic model that accounts for
Identifiants
pubmed: 35425808
doi: 10.3389/fmolb.2022.801032
pii: 801032
pmc: PMC9001882
doi:
Types de publication
Journal Article
Langues
eng
Pagination
801032Informations de copyright
Copyright © 2022 Boada, Santos-Navarro, Picó and Vignoni.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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