An epidemiological study of pediatric COVID-19 in the era of the variant of concern.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
01
2022
accepted:
31
03
2022
entrez:
15
4
2022
pubmed:
16
4
2022
medline:
20
4
2022
Statut:
epublish
Résumé
There were limited epidemiological data of pediatric COVID-19 in Asia outside China, especially during the era of the variants of concern such as the Delta and Alpha variants. The objective was to describe the clinical epidemiology of pediatric COVID-19 in a tertiary care center in Thailand from April to August 2021. The identification of risk factors for the development of pneumonia in these children was also performed. This retrospective cohort study was conducted by retrospective chart review of all children aged 0-15 years admitted to Thammasat University Hospital care system during the study period. The risk factors for the development of pneumonia were analyzed using logistic regression. A total of 698 children were included for analysis, of which 52% were male. The mean age of the cohort was 7.2 + 4.5 years old. Radiographic pneumonia was identified in 100 children (14.3%) and a total of 16 children (2.3%) were diagnosed with severe and critical diseases. The mortality rate was 0.1%. Children younger than 1 year and children with comorbidity were at higher risk of developing pneumonia (Adjusted odds ratios 2.99 (95% confidence interval (CI): 1.56-5.74) and 2.32 (95% CI: 1.15-4.67), respectively). In the era of the variants of concern, the proportion of children with severe and critical diseases remained low. However, prudence must be taken in caring for younger children and children with comorbidity.
Sections du résumé
BACKGROUND
There were limited epidemiological data of pediatric COVID-19 in Asia outside China, especially during the era of the variants of concern such as the Delta and Alpha variants. The objective was to describe the clinical epidemiology of pediatric COVID-19 in a tertiary care center in Thailand from April to August 2021. The identification of risk factors for the development of pneumonia in these children was also performed.
METHODS
This retrospective cohort study was conducted by retrospective chart review of all children aged 0-15 years admitted to Thammasat University Hospital care system during the study period. The risk factors for the development of pneumonia were analyzed using logistic regression.
RESULTS
A total of 698 children were included for analysis, of which 52% were male. The mean age of the cohort was 7.2 + 4.5 years old. Radiographic pneumonia was identified in 100 children (14.3%) and a total of 16 children (2.3%) were diagnosed with severe and critical diseases. The mortality rate was 0.1%. Children younger than 1 year and children with comorbidity were at higher risk of developing pneumonia (Adjusted odds ratios 2.99 (95% confidence interval (CI): 1.56-5.74) and 2.32 (95% CI: 1.15-4.67), respectively).
CONCLUSION
In the era of the variants of concern, the proportion of children with severe and critical diseases remained low. However, prudence must be taken in caring for younger children and children with comorbidity.
Identifiants
pubmed: 35427379
doi: 10.1371/journal.pone.0267035
pii: PONE-D-22-00667
pmc: PMC9012366
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0267035Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Med J Armed Forces India. 2020 Oct;76(4):370-376
pubmed: 32895599
Pediatrics. 2020 Jun;145(6):
pubmed: 32179660
J Med Virol. 2021 Feb;93(2):1057-1069
pubmed: 32761898
Int J Infect Dis. 2021 Feb;103:246-256
pubmed: 33227520
Am J Trop Med Hyg. 2021 Jun 15;105(2):413-420
pubmed: 34129517
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
EClinicalMedicine. 2020 Jun 26;24:100433
pubmed: 32766542
N Engl J Med. 2020 Mar 26;382(13):1199-1207
pubmed: 31995857
Pediatr Nephrol. 2021 Nov;36(11):3771-3776
pubmed: 34021797
Pediatrics. 2020 Oct;146(4):
pubmed: 32665373